Chemical constituents and antileukemic activity of Eugenia dysenterica
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2017
Autores
Vitek, Renan
de Novais, Leice M. R.
Torquato, Heron F. V. [UNIFESP]
Paredes-Gamero, Edgar J. [UNIFESP]
de Carvalho, Mario G.
de Sousa, Paulo T., Jr.
Jacinto, Marcos J.
da Silva, Virginia C.
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The study about Eugenia dysenterica led to the isolation of 3-acetyl-urs-12-en-28-oic (1), 3-acetyl-olean-12-en-28-oic acid (2) and isoquercetin (3) from the stem barks, and of 3-O--glucopyranosyl--sitosterol (4), methyl 3-hydroxy-4-methoxybenzoate (5), methyl 4-hydroxyphenyl propionate (6), E-methyl-4-hydroxycinnamate (7), quercetin-3-O-(6??-O-galloyl)--d-glucopyranoside (8) and quercetin-3-O--d-galactopyranoside (9) from the leaves. The structures 1-9 were set through the analysis of their NMR spectroscopic data. Compounds 2, 3 and 5-8 were reported for the first time in the Eugenia genus. Compound 8 reduced cell viability and presented IC50 values 40.3 and 36.7M, for the CCRF-CEM and the Kasumi-1 cells, respectively. [GRAPHICS] .
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Natural Product Research. Abingdon, v. 31, n. 16, p. 1930-1934, 2017.