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dc.contributor.authorLeite, Marcel [UNIFESP]
dc.contributor.authorCompagnoli Carmona, Rita de Cassia
dc.contributor.authorCarraro, Emerson
dc.contributor.authorAranha Watanabe, Aripuana Sakurada [UNIFESP]
dc.contributor.authorHernandes Granato, Celso Francisco [UNIFESP]
dc.date.accessioned2020-07-17T14:03:33Z
dc.date.available2020-07-17T14:03:33Z
dc.date.issued2017
dc.identifierhttp://dx.doi.org/10.1590/S1678-9946201759045
dc.identifier.citationRevista Do Instituto De Medicina Tropical De Sao Paulo. Sao Paulo, v. 59, p. -, 2017.
dc.identifier.issn0036-4665
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55497
dc.description.abstractRotavirus is the main global cause of severe childhood diarrhoea among children. In 2006, Rotarix r (G1P[8]) was introduced into Brazil's National Immunization Program. The vaccine coverage rate was 84.4% in 2009. Evidences of increasing G2P[4] after 2006 opened up the discussion about the vaccine effectiveness to non-G1 strains. The aim of this study was to identify the circulating rotavirus genotypes in two Brazilian regions during 2009. A total of 223 positive samples by immunochromatography and latex agglutination assay from the Northeast (Bahia/Pernambuco States) and Southeast (Sao Paulo/Rio de Janeiro States) regions were included in the study. The samples were submitted to genotyping by nested-PCR according to VP7(G) and VP4(P) and 175 samples (78.5%) were able to be characterized. Considering the characterization of VP7, the G-types detected were G1, G2, and G4 in the Northeast, and G2, G3, G5, and G9 in the Southeast. Considering the characterization of VP4, the P-types detected were P[4], P[8], and P[6]/P[9] in the Northeast and the Southeast. The most frequent mixed types found were G2P[4]/G2P[NT](81.4%), G2P[6](5.2%), G1P[6](5.2%) in the Northeast, and G2P[4]/G2P[NT](78.8%), G2P[6](8.2%), G9P[8](4.7%) in the Southeast. Among immunized individuals whose age ranged from 0- 4 years, the G2P[4]/G2P[NT] genotype was identified in 91,0% of cases, and among non-immunized individuals of the same age, the G2P[4]/G2P[NT] genotype was identified in 85.7% of the cases. In accordance with the high level of vaccine coverage, the data suggest that the circulation of G2P[4] in these regions had a considerable increase after the introduction of Rotarix (R).en
dc.description.sponsorshipFederal University of Sao Paulo
dc.description.sponsorshipFleury Group
dc.format.extent-
dc.language.isoeng
dc.publisherInst Medicina Tropical Sao Paulo
dc.relation.ispartofRevista Do Instituto De Medicina Tropical De Sao Paulo
dc.rightsAcesso aberto
dc.subjectRotavirusen
dc.subjectEpidemiologyen
dc.subjectGenotypeen
dc.subjectVaccineen
dc.titleRotavirus genotypes as etiological agents of diarrhoea in general populations of two geographic regions of Brazilen
dc.typeArtigo
dc.description.affiliationGrp Fleury Automacao, Av Gen Waldomiro Lima 508, BR-04344070 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Med, Lab Virol Clin, Unidade Doencas Infecciosas, Sao Paulo, SP, Brazil
dc.description.affiliationAdolfo Lutz Inst, Nucl Doencas Enter, Ctr Virol, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Estadual Centro Oeste, Guarapuava, Parana, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Med, Lab Virol Clin, Unidade Doencas Infecciosas, Sao Paulo, SP, Brazil
dc.identifier.fileS0036-46652017005000223.pdf
dc.identifier.scieloS0036-46652017005000223
dc.identifier.doi10.1590/S1678-9946201759045
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000407427600002
dc.coverageSao Paulo
dc.citation.volume59


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