Analytical approaches for lipidomics and its potential applications in neuropsychiatric disorders

Analytical approaches for lipidomics and its potential applications in neuropsychiatric disorders

Author Sethi, Sumit Autor UNIFESP Google Scholar
Hayashi, Mirian A. Autor UNIFESP Google Scholar
Sussulini, Alessandra Google Scholar
Tasic, Ljubica Google Scholar
Brietzke, Elisa Autor UNIFESP Google Scholar
Abstract Objectives: In this review, the authors discuss an overview of lipidomics followed by in-depth discussion of its application to the study of human diseases, including extraction methods of lipids, analytical techniques and clinical research in neuropsychiatric disorders. Methods: Lipidomics is a lipid-targeted metabolomics approach aiming at the comprehensive analysis of lipids in biological systems. Recent technological advancements in mass spectrometry and chromatography have greatly enhanced the development and applications of metabolic profiling of diverse lipids in complex biological samples. Results: An effective evaluation of the clinical course of diseases requires the application of very precise diagnostic and assessment approaches as early as possible. In order to achieve this, omics strategies offer new opportunities for biomarker identification and/or discovery in complex diseases and may provide pathological pathways understanding for diseases beyond traditional methodologies. Conclusions: This review highlights the importance of lipidomics for the future perspectives as a tool for biomarker identification and discovery and its clinical application.
Keywords Biomarkers
bipolar disorder
lipidomics
major depressive disorder
schizophrenia
xmlui.dri2xhtml.METS-1.0.item-coverage Abingdon
Language English
Sponsor Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq, Brasilia, Brazil)
Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP, Sao Paulo, Brazil)
CNPq
Fundo de Apoio ao Ensino, a Pesquisa e a Extensao (FAEPEX) from the Universidade Estadual de Campinas
Grant number CNPq: 454234/2014-7
FAPESP: 2014/18938-8
FAEPEX/UNICAMP: 1244/14
Date 2017
Published in World Journal Of Biological Psychiatry. Abingdon, v. 18, n. 7, p. 506-520, 2017.
ISSN 1562-2975 (Sherpa/Romeo, impact factor)
Publisher Taylor & Francis Ltd
Extent 506-520
Origin http://dx.doi.org/10.3109/15622975.2015.1117656
Access rights Closed access
Type Article
Web of Science ID WOS:000410902200003
URI https://repositorio.unifesp.br/handle/11600/55468

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