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dc.contributor.authorWakamatsu, Tais H. [UNIFESP]
dc.contributor.authorUeta, Mayumi
dc.contributor.authorTokunaga, Katsushi
dc.contributor.authorOkada, Yukinori
dc.contributor.authorLoureiro, Renata R. [UNIFESP]
dc.contributor.authorCosta, Karita A. [UNIFESP]
dc.contributor.authorSallum, Juliana Maria F. [UNIFESP]
dc.contributor.authorMilhomens, Jose Arthur [UNIFESP]
dc.contributor.authorInoue, Chikara
dc.contributor.authorSotozono, Chie
dc.contributor.authorGomes, Jose Alvaro P. [UNIFESP]
dc.contributor.authorKinoshita, Shigeru
dc.identifier.citationJama Ophthalmology. Chicago, v. 135, n. 4, p. 355-360, 2017.
dc.description.abstractIMPORTANCE Describing the association with human leukocyte antigen (HLA) alleles could facilitate the understanding of increased risk factors for development of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in patients with severe ocular complications (SOCs). OBJECTIVE To investigate the association between HLA class I genes and cold medicine (CM)-associated SJS/TEN with SOCs. DESIGN, SETTING, AND PARTICIPANTS This case-control studywas conducted between February 8, 2013, and August 29, 2014. Thirty-nine Brazilian patients with CM-SJS/TEN of 74 patients with SJS/TEN with SOCs and 133 healthy Brazilian volunteers were enrolled. Human leukocyte antigen class I genes (HLA-A, HLA-B, and HLA-C) were examined to determine whether there was a genetic predisposition for CM-SJS/TEN with SOC. Patients were interviewed to identify possible etiologic factors. Data analysis was performed from April 14, 2013, to August 29, 2014. MAIN OUTCOMES AND MEASURES Genetic predisposition for CM-SJS/TEN with SOCs by analysis of HLA class I genes. RESULTS Of 74 patients included in the analysis, 32 (43%) were maleen
dc.description.abstractmean (SD) age was 36.01 [15.42] years. HLA-A*66: 01 (odds ratio [OR], 24.0en
dc.description.abstract95% CI, 2.79-206.0en
dc.description.abstractP < 001), HLA-B*44: 03 (OR, 2.71en
dc.description.abstract95% CI, 1.11-6.65en
dc.description.abstractP = 04), and HLA-C*12: 03 (OR, 5.6en
dc.description.abstract95% CI, 1.67-18.80en
dc.description.abstractP = 006) were associated with Brazilian CM-SJS/TEN with SOCs, and HLA-A*11: 01 (OR, 0.074en
dc.description.abstract95% CI, 0.004-1.26en
dc.description.abstractP = 008), HLA-B*08: 01 (OR, 0.15en
dc.description.abstract95% CI, 0.02-1.15en
dc.description.abstractP = 048), and HLA-B*51: 01 (OR, 0.23en
dc.description.abstract95% CI, 0.05-1.03en
dc.description.abstractP = 045) were inversely associated with Brazilian CM-SJS/TEN with SOCs (39 cases: 19 Pardo and 16 European ancestryen
dc.description.abstract14 males and 25 femalesen
dc.description.abstractage, 35.2 [14.4] yearsen
dc.description.abstractand 133 controls: 66 Pardo and 61 European ancestryen
dc.description.abstract55 males and 78 femalesen
dc.description.abstractage, 41.2 [12.9] years). When multiple test correction within the HLA locus, HLA-A*66: 01 and HLA-C*12: 03 demonstrated associations. When participants were segregated into Pardo and locus is considered, HLA-A*66: 01 was associated with CM-SJS/TEN with SOC among individuals of both ethnic groups (Pardo: OR, 12.2en
dc.description.abstract95% CI, 1.19-125.0en
dc.description.abstractP = 03en
dc.description.abstractand European: OR, 21.2en
dc.description.abstract95% CI, 0.97-465.0en
dc.description.abstractP = 04). An association was observed only in the European cohort for HLA-B*44: 03 (OR, 5.50en
dc.description.abstract95% CI, 1.47-20.50en
dc.description.abstractP = 01) and HLA-C*12: 03 (OR, 8.79en
dc.description.abstract95% CI, 1.83-42.20en
dc.description.abstractP = 008). CONCLUSIONS AND RELEVANCE This study suggests that HLA-A*66: 01 might be a marker for CM-SJS/TEN with SOCs in Brazilian individuals of Pardo and European ancestry and that HLA-B*44: 03 and HLA-C*12: 03 might be markers only in those of European ancestry. Moreover, HLA-A*11: 01 might be a marker of resistance to CM-SJS/TEN with SOCs.en
dc.description.sponsorshipMinistry of Education, Culture, Sports, Science and Technology of the Japanese government
dc.description.sponsorshipJapan Society for the Promotion of Science Core-to-Core Program Advanced Research Networks
dc.description.sponsorshipJapanese Ministry of Health, Labor and Welfare
dc.description.sponsorshipKyoto Foundation for the Promotion of Medical Science and the Intramural Research Fund of Kyoto Prefectural University of Medicine
dc.description.sponsorshipMinistry of Education, Brazil-Japan
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo
dc.publisherAmer Medical Assoc
dc.relation.ispartofJama Ophthalmology
dc.rightsAcesso aberto
dc.titleHuman Leukocyte Antigen Class I Genes Associated With Stevens-Johnson Syndrome and Severe Ocular Complications Following Use of Cold Medicine in a Brazilian Populationen
dc.description.affiliationUniv Fed Sao Paulo, Dept Ophthalmol, Sao Paulo, Brazil
dc.description.affiliationPrefectural Univ Med, Dept Frontier Med Sci & Technol Ophthalmol, Kyoto, Japan
dc.description.affiliationUniv Tokyo, Grad Sch Med, Dept Human Genet, Tokyo, Japan
dc.description.affiliationOsaka Univ, Dept Stat Genet, Osaka, Japan
dc.description.affiliationRIKEN, Lab Stat Anal, Ctr Integrat Med Sci, Yokohama, Kanagawa, Japan
dc.description.affiliationKyoto Prefectural Univ Med, Dept Ophthalmol, Kyoto, Japan
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Ophthalmol, Sao Paulo, Brazil
dc.description.sourceWeb of Science

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