Clinical impact of thyroglobulin (Tg) and Tg autoantibody (TgAb) measurements in needle washouts of neck lymph node biopsies in the management of patients with papillary thyroid carcinoma

Clinical impact of thyroglobulin (Tg) and Tg autoantibody (TgAb) measurements in needle washouts of neck lymph node biopsies in the management of patients with papillary thyroid carcinoma

Author Cecilia Martins-Costa, M. Autor UNIFESP Google Scholar
Maciel, Rui M. B. Autor UNIFESP Google Scholar
Kasamatsu, Teresa S. Google Scholar
Nakabashi, Claudia C. D. Autor UNIFESP Google Scholar
Camacho, Cleber P. Autor UNIFESP Google Scholar
Crispim, Felipe Autor UNIFESP Google Scholar
Ikejiri, Elza S. Autor UNIFESP Google Scholar
Mamone, M. Conceicao O. Autor UNIFESP Google Scholar
Andreoni, Danielle M. Autor UNIFESP Google Scholar
Biscolla, Rosa Paula M. Autor UNIFESP Google Scholar
Abstract Objectives: The presence of thyroglobulin (Tg) in needle washouts of fine needle aspiration biopsy (Tg-FNAB) in neck lymph nodes (LNs) suspected of metastasis has become a cornerstone in the followup of patients with papillary thyroid carcinoma (PTC). However, there are limited data regarding the measurement of anti-Tg antibodies in these washouts (TgAb-FNAB), and it is not clear whether these antibodies interfere with the assessment of Tg-FNAB or whether there are other factors that would more consistently justify the finding of low Tg-FNAB in metastatic LNs. Materials and methods: We investigated 232 FNAB samples obtained from suspicious neck LNs of 144 PTC patients. These samples were divided according to the patient's serum TgAb status: sTgAb-(n = 203 samples) and sTgAb+ (n = 29). The TgAb-FNAB levels were measured using two different assays. Tg-FNAB was also measured using two assays when low levels (< 10 ng/mL) were identified in the first assay of the metastatic LNs from the sTgAb+ samples. Results: The TgAb-FNAB results were negative in both assays in all samples. Low levels of Tg-FNAB were identified in 11/16 of the metastatic LNs of the sTgAb+ patients and 16/63 of the sTgAb-patients (p < 0.05) using assay 1. The measurement of the Tg-FNAB levels using assay 2 indicated additional metastases in 5 LNs of the sTgAb+ patients. Conclusions: Factors other than the presence of TgAb-FNAB may contribute to the higher number of metastatic LNs with undetectable Tg-FNAB in the sTgAb+ group. In addition, the measurement of Tg-FNAB using different assays was useful to enhance the diagnosis of metastatic LNs, particularly when cytological and Tg-FNAB results are discordant.
Keywords Fine needle aspiration biopsy
anti-thyroglobulin antibody
thyroglobulin
papillary thyroid cancer
neck lymph nodes
xmlui.dri2xhtml.METS-1.0.item-coverage Rio De Janeiro, Rj
Language English
Sponsor Sao Paulo State Research Foundation [Fapesp-09/50573-1]
Brazilian Ministry of Health [25000.168513/2008-11]
Date 2017
Published in Archives Of Endocrinology Metabolism. Rio De Janeiro, Rj, v. 61, n. 2, p. 108-114, 2017.
ISSN 2359-3997 (Sherpa/Romeo, impact factor)
Publisher Sbem-Soc Brasil Endocrinologia & Metabologia
Extent 108-114
Origin http://dx.doi.org/10.1590/2359-3997000000241
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000400548000003
SciELO ID S2359-39972017000200108 (statistics in SciELO)
URI https://repositorio.unifesp.br/handle/11600/54800

Show full item record




File

Name: S2359-39972017000200108.pdf
Size: 168.2Kb
Format: PDF
Description:
Open file

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account