Antileishmanial Activity and Immunomodulatory Effects of Tricin Isolated from Leaves of Casearia arborea (Salicaceae)
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Data
2017
Autores
Santos, Augusto L. [UNIFESP]
Yamamoto, Eduardo S.
Passero, Luiz Felipe D.
Laurenti, Marcia D.
Martins, Ligia F.
Lima, Marta L.
Uemi, Miriam [UNIFESP]
Soares, Marisi G.
Lago, Joao Henrique G.
Tempone, Andre G.
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Bioactivity-guided fractionation of antileishmanial active extract from leaves of Casearia arborea led to isolation of three metabolites: tricin (1), 1,6 '-di-O-beta-D-vanilloyl glucopyranoside (2) and vanillic acid (3). Compound 1 demonstrated the highest activity against the intracellular amastigotes of Leishmania infantum, with an IC50 value of 56 mu m. Tricin (1) demonstrated selectivity in mammalian cells (SI > 7) and elicited immunomodulatory effect on host cells. The present work suggests that tricin modulated the respiratory burst of macrophages to a leishmanicidal state, contributing to the parasite elimination. Therefore, the natural compound tricin could be further explored in drug design studies for leishmaniasis treatment.
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Chemistry & Biodiversity. Weinheim, v. 14, n. 5, p. -, 2017.