Maternal obesity and inflammatory mediators: A controversial association

Maternal obesity and inflammatory mediators: A controversial association

Author Pendeloski, Karen Priscilla Tezotto Autor UNIFESP Google Scholar
Ono, Erika Autor UNIFESP Google Scholar
Torloni, Maria ReginaV Google Scholar
Mattar, RosianeV Autor UNIFESP Google Scholar
Daher, Silvia Autor UNIFESP Google Scholar
Abstract The link between maternal obesity and inflammatory mediators is still unclear. Our aim was to summarize the main findings of recently published studies on this topic. We performed a search in Medline for studies published in the last years on obesity, human pregnancy, and inflammatory mediators. We report the findings of 30 studies. The characteristics and number of participants, study design, gestational age at sample collection, and type of sample varied widely. Approximately two-thirds of them investigated more than one mediator, and 50% included participants in only one trimester of pregnancy. The most frequently investigated mediators were leptin, tumour necrosis factor-alpha (TNF-alpha), and interleukin (IL)-6. Almost all studies reported an association between maternal obesity, leptin, and C-reactive protein (CRP) serum levels but not with IL-1 beta and IL-10. The association of IL-6, TNF-alpha, monocyte chemo-attractant protein-1 (MCP-1), adiponectin, and resistin with maternal obesity is still controversial. To clarify the physiopathological link between maternal obesity and inflammation, more high-quality studies are needed.
Keywords adipokine
inflammatory mediator
maternal obesity
xmlui.dri2xhtml.METS-1.0.item-coverage Hoboken
Language English
Sponsor Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
Conselho Nacional de Desenvolvimento Cientifico e Tecnologico
Grant number FAPESP: 2013/22754-7
CAPES: 307337/2012-0
Date 2017
Published in American Journal Of Reproductive Immunology. Hoboken, v. 77, n. 5, p. -, 2017.
ISSN 1046-7408 (Sherpa/Romeo, impact factor)
Publisher Wiley
Extent -
Access rights Closed access
Type Article
Web of Science ID WOS:000401261200011

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