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dc.contributor.authorAdachi, Kristina
dc.contributor.authorXu, Jiahong
dc.contributor.authorYeganeh, Nava
dc.contributor.authorCamarca, Margaret
dc.contributor.authorMorgado, Mariza G.
dc.contributor.authorWatts, D. Heather
dc.contributor.authorMofenson, Lynne M.
dc.contributor.authorVeloso, Valdilea G.
dc.contributor.authorPilotto, Jose Henrique
dc.contributor.authorJoao, Esau
dc.contributor.authorGray, Glenda
dc.contributor.authorTheron, Gerhard
dc.contributor.authorSantos, Breno
dc.contributor.authorFonseca, Rosana
dc.contributor.authorKreitchmann, Regis
dc.contributor.authorPinto, Jorge
dc.contributor.authorMussi-Pinhata, Marisa M.
dc.contributor.authorCeriotto, Mariana
dc.contributor.authorMachado, Daisy Maria [UNIFESP]
dc.contributor.authorBryson, Yvonne J.
dc.contributor.authorGrinsztejn, Beatriz
dc.contributor.authorMoye, Jack
dc.contributor.authorKlausner, Jeffrey D.
dc.contributor.authorBristow, Claire C.
dc.contributor.authorDickover, Ruth
dc.contributor.authorMirochnick, Mark
dc.contributor.authorNielsen-Saines, Karin
dc.date.accessioned2020-07-08T13:09:53Z
dc.date.available2020-07-08T13:09:53Z
dc.date.issued2018
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0189851
dc.identifier.citationPlos One. San Francisco, v. 13, n. 1, p. -, 2018.
dc.identifier.issn1932-6203
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54274
dc.description.abstractBackground Sexually transmitted infections (STIs) including Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), Treponema pallidum (TP), and cytomegalovirus (CMV) may lead to adverse pregnancy and infant outcomes. The role of combined maternal STIs in HIV mother-to-child transmission (MTCT) was evaluated in mother-infant pairs from NICHD HPTN 040. Methodology Urine samples from HIV-infected pregnant women during labor were tested by polymerase chain reaction (PCR) for CT, NG, and CMV. Infant HIV infection was determined by serial HIV DNA PCR testing. Maternal syphilis was tested by VDRL and confirmatory treponemal antibodies. Results A total of 899 mother-infant pairs were evaluated. Over 30% had at least one of the following infections (TP, CT, NG, and/or CMV) detected at the time of delivery. High rates of TP (8.7%), CT (17.8%), NG (4%), and CMV (6.3%) were observed. HIV MTCT was 9.1% (n = 82 infants). HIV MTCT was 12.5%, 10.3%, 11.1%, and 26.3% among infants born to women with CT, TP, NG or CMV respectively. Forty-two percent of HIV-infected infants were born to women with at least one of these 4 infections. Women with these infections were nearly twice as likely to have an HIV-infected infant (aOR 1.9, 95% CI 1.1-3.0), particularly those with 2 STIs (aOR 3.4, 95% CI 1.5-7.7). Individually, maternal CMV (aOR 4.4 1.5-13.0) and infant congenital CMV (OR 4.1, 95% CI 2.2-7.8) but not other STIs (TP, CT, or NG) were associated with an increased risk of HIV MTCT. Conclusion HIV-infected pregnant women identified during labor are at high risk for STIs. Co-infection with STIs including CMV nearly doubles HIV MTCT risk. CMV infection appears to confer the largest risk of HIV MTCT.en
dc.description.sponsorshipNICHD (NICHD)
dc.description.sponsorship(Brazilian AIDS Prevention Trials International Network), NIAID/ NIH
dc.description.sponsorshipNational Institute of Allergy and Infectious Diseases (NIAID)
dc.description.sponsorshipEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
dc.description.sponsorshipNational Institute of Mental Health (NIMH)
dc.description.sponsorshipBoehringer Ingelheim Pharmaceuticals Inc. (BIPI)
dc.description.sponsorshipGlaxoSmithKline, on behalf of ViiV Healthcare
dc.description.sponsorshipCepheid for the testing of CT
dc.description.sponsorshipNG in a prior HPTN
dc.description.sponsorshipUCLA Children's Discovery and Innovation Institute (CDI) through the Harry Winston Fellowship Award
dc.description.sponsorshipUCLA AIDS Institute
dc.description.sponsorshipUCLA Center for AIDS Research (CFAR) NIH/ NIAID
dc.description.sponsorshipUCLA Pediatric AIDS Coalition, and Westat
dc.description.sponsorshipNIH/NICHD
dc.format.extent-
dc.language.isoeng
dc.publisherPublic Library Science
dc.relation.ispartofPlos One
dc.rightsAcesso aberto
dc.titleCombined evaluation of sexually transmitted infections in HIV-infected pregnant women and infant HIV transmissionen
dc.typeArtigo
dc.description.affiliationDavid Geffen UCLA Sch Med, Los Angeles, CA 90095 USA
dc.description.affiliationWestat Corp, Rockville, MD USA
dc.description.affiliationFundacao Oswaldo Cruz FIOCRUZ, Rio De Janeiro, RJ, Brazil
dc.description.affiliationUS Dept State, Off Global AIDS Coordinator, Washington, DC 20520 USA
dc.description.affiliationElizabeth Glaser Pediat AIDS Fdn, Washington, DC USA
dc.description.affiliationHosp Geral Nova Iguacu, Nova Iguacu, RJ, Brazil
dc.description.affiliationHosp Fed Servidores Estado, Rio De Janeiro, RJ, Brazil
dc.description.affiliationUniv Witwatersrand, SAMRC & Perinatal HIV Res Unit, Johannesburg, South Africa
dc.description.affiliationStellenbosch Univ, Tygerberg Hosp, Cape Town, South Africa
dc.description.affiliationHosp Conceicao, Porto Alegre, RS, Brazil
dc.description.affiliationHosp Femina, Porto Alegre, RS, Brazil
dc.description.affiliationIrmandade Santa Casa Misericordia Porto Alegre, Porto Alegre, RS, Brazil
dc.description.affiliationUniv Fed Minas Gerais, Belo Horizonte, MG, Brazil
dc.description.affiliationUniv Sao Paulo, Ribeirao Preto Med Sch, Sao Paulo, Brazil
dc.description.affiliationFdn Maternal & Infant Hlth FUNDASAMIN, Buenos Aires, DF, Argentina
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Sao Paulo, SP, Brazil
dc.description.affiliationEunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Bethesda, MD USA
dc.description.affiliationUCLA, Fielding Sch Publ Hlth, Los Angeles, CA USA
dc.description.affiliationUCSD Sch Med, La Jolla, CA USA
dc.description.affiliationUC Davis Sch Med, Davis, CA USA
dc.description.affiliationBoston Univ, Sch Med, Boston, MA 02118 USA
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Sao Paulo, SP, Brazil
dc.description.sponsorshipIDNICHD (NICHD): HHSN267200800001C, N01-HD-8-0001
dc.description.sponsorshipIDBrazilian AIDS Prevention Trials International Network: NIAID/ NIH [U01 AI047986
dc.description.sponsorshipIDNational Institute of Allergy and Infectious Diseases (NIAID): U01 AI068632, UM1AI068632, UM1AI068616, UM1AI106716
dc.description.sponsorshipIDNIMH: AI068632
dc.description.sponsorshipIDNG in a prior HPTN :040
dc.description.sponsorshipIDUCLA Center for AIDS Research (CFAR) NIH/ NIAID: AI02869, AI28697
dc.description.sponsorshipIDNIH/NICHD: HHSN275201300003C
dc.identifier.fileWOS000419403800025.pdf
dc.identifier.doi10.1371/journal.pone.0189851
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000419403800025
dc.coverageSan Francisco
dc.citation.volume13
dc.citation.issue1


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