Morpho/Proteomic Comparative between High Grade Pleomorphic Sarcoma and Metastasis Diagnosed in an Old Captive Common Hippo

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dc.contributor.author Silva, Adriana R. [UNIFESP]
dc.contributor.author de Lacerda, Jose T. J. G. [UNIFESP]
dc.contributor.author Faria, Bernadete [UNIFESP]
dc.contributor.author da Cunha, Isabela W.
dc.contributor.author de Andrade, Vitor P.
dc.contributor.author Assuncao, Nilson A. [UNIFESP]
dc.date.accessioned 2020-07-08T13:09:51Z
dc.date.available 2020-07-08T13:09:51Z
dc.date.issued 2018
dc.identifier http://dx.doi.org/10.21577/0103-5053.20170149
dc.identifier.citation Journal Of The Brazilian Chemical Society. Sao Paulo, v. 29, n. 2, p. 363-370, 2018.
dc.identifier.issn 0103-5053
dc.identifier.uri https://repositorio.unifesp.br/handle/11600/54245
dc.description.abstract Old age is a risk factor for cancer development in humans and animals, and studies have shown that tumors in animals are acceptable models for studying human cancers, considering the similarities between their factors. This work was conducted in a 53-year-old captive female common hippo (Hippopotamus amphibious) with a left leg tumor and metastatic mass. Histopathological and immunohistochemical analyses were carried out with a final diagnosis of a high grade pleomorphic sarcoma. A proteomic study using mass spectrometry was added in order to identify further aspects of the primary tumor and metastasis which could improve our understanding, and each tissue showed a proteomic profile indicative of its pathologic state with significant differences between healthy tissue, primary and metastatic tumors. Low levels of beta-actin in primary tumors were identified, and this may be associated with a possible consequence of cytoskeleton dynamic modification. In metastatic tissue, these dynamics may be affected by the presence of HSP chaperone 60. en
dc.description.sponsorship FAPESP: 2012/02514-9
dc.format.extent 363-370
dc.language.iso eng
dc.publisher Soc Brasileira Quimica
dc.relation.ispartof Journal Of The Brazilian Chemical Society
dc.rights Acesso aberto
dc.subject Hippopotamus amphibious en
dc.subject high grade pleomorphic sarcoma en
dc.subject cytoskeleton en
dc.subject beta-actin en
dc.subject mass spectrometry en
dc.title Morpho/Proteomic Comparative between High Grade Pleomorphic Sarcoma and Metastasis Diagnosed in an Old Captive Common Hippo en
dc.type Artigo
dc.description.affiliation Univ Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, BR-04039032 Diadema, SP, Brazil
dc.description.affiliation Univ Fed Sao Paulo, Escola Paulista Med, BR-04023062 Sao Paulo, SP, Brazil
dc.description.affiliation AC Camargo Canc Ctr, Dept Patol, BR-01509010 Sao Paulo, SP, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, BR-04039032 Diadema, SP, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Escola Paulista Med, BR-04023062 Sao Paulo, SP, Brazil
dc.identifier.file S0103-50532018000200363.pdf
dc.identifier.scielo S0103-50532018000200363
dc.identifier.doi 10.21577/0103-5053.20170149
dc.description.source Web of Science
dc.identifier.wos WOS:000416209700017
dc.coverage Sao Paulo
dc.citation.volume 29
dc.citation.issue 2



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