Effects of the brain-derived neurotropic factor variant Val66Met on cortical structure in late childhood and early adolescence

Effects of the brain-derived neurotropic factor variant Val66Met on cortical structure in late childhood and early adolescence

Author de Araujo, Celia Maria Autor UNIFESP Google Scholar
Zugman, Andre Autor UNIFESP Google Scholar
Swardfager, Walter Google Scholar
Nogueira Belangero, Sintia Iole Autor UNIFESP Google Scholar
Ota, Vanessa Kiyomi Autor UNIFESP Google Scholar
Spindola, Leticia Maria Autor UNIFESP Google Scholar
Hakonarson, Hakon Google Scholar
Pellegrino, Renata Google Scholar
Gadelha, Ary Autor UNIFESP Google Scholar
Salum, Giovanni Abrahao Google Scholar
Pan, Pedro Mario Autor UNIFESP Google Scholar
de Moura, Luciana Monteiro Google Scholar
Del Aquilla, Marco Autor UNIFESP Google Scholar
Picon, Felipe Almeida Google Scholar
Amaro, Edson, Jr. Google Scholar
Sato, Joao Ricardo Google Scholar
Brietzke, Elisa Autor UNIFESP Google Scholar
Grassi-Oliveira, Rodrigo Google Scholar
Rohde, Luis Augusto P. Google Scholar
Miguel, Euripedes Constantino Google Scholar
Bressan, Rodrigo A. Autor UNIFESP Google Scholar
Jackowski, Andrea Parolin Autor UNIFESP Google Scholar
Abstract Background: The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism (rs6265) has been associated with several neuropsychiatric disorders and regional structural brain changes in adults, but little is known about Val66Met's effect on brain morphology during typical or atypical neurodevelopment. Windows of vulnerability to psychopathology may be associated with the different alleles of the Val66Met polymorphism during childhood and adolescence. Methodology: We investigated the effect of Val66Met on cortical thickness in MRI scans of 718 children and adolescents (6-12 years old) with typical development, and in those meeting DSM criteria for a psychiatric disorder. Results: Val66Met had a significant effect on cortical thickness. Considering the typically developing group, Met carriers presented thicker parietal and occipital lobes and prefrontal cortices compared to Val homozygotes. Met carriers with psychiatric disorders presented thicker medial and lateral temporal cortices than Val homozygotes. Furthermore, a significant genotype x psychiatric diagnosis interaction was found: Met-carriers with a psychiatric diagnosis presented thinner bilateral prefrontal cortices than Val homozygotes. Conclusion: This study provides evidence that Val66Met is associated with cortical maturation in children and adolescents with and without psychiatric disorders.
Keywords Brain-derived neurotrophic factor
Psychiatric disorders
Brain morphology
Cortical thickness
xmlui.dri2xhtml.METS-1.0.item-coverage Oxford
Language English
Sponsor National Institute of Developmental Psychiatry for Children and Adolescent (INPD) [CNPq 465550/2014-2, FAPESP 2014/50917-0]
Sunnybrook Health Sciences Centre
Sunnybrook Research Institute
Centre for Collaborative Drug Research
Canadian Partnership for Stroke Recovery
Sao Paulo Research Foundation (FAPESP) [2013/08531-5]
Brazilian National Council for Scientific and Technological Development (CNPq) [312984/2014-6, 442026/2014-5]
FAPESP [2014/07280-1]
Grant number CNPq 465550/2014-2
FAPESP 2014/50917-0
FAPESP: 2013/08531-5
CNPq: [312984/2014-6, 442026/2014-5
FAPESP: 2014/07280-1
Date 2018
Published in Journal Of Psychiatric Research. Oxford, v. 98, p. 51-58, 2018.
ISSN 0022-3956 (Sherpa/Romeo, impact factor)
Publisher Pergamon-Elsevier Science Ltd
Extent 51-58
Origin http://dx.doi.org/10.1016/j.jpsychires.2017.12.008
Access rights Closed access
Type Article
Web of Science ID WOS:000425076000008
URI https://repositorio.unifesp.br/handle/11600/54085

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