Nandrolone combined with strenuous resistance training reduces vascular nitric oxide bioavailability and impairs endothelium-dependent vasodilation

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dc.contributor.author Guzzoni, Vinicius
dc.contributor.author Cunha, Tatiana Sousa [UNIFESP]
dc.contributor.author das Neves, Vander Jose
dc.contributor.author Briet, Larissa
dc.contributor.author Costa, Rafaela
dc.contributor.author Costa Sampaio Moura, Maria Jose
dc.contributor.author Oliveira, Vanessa [UNIFESP]
dc.contributor.author Pinho Franco, Maria do Carmo [UNIFESP]
dc.contributor.author Novaes, Pedro Duarte
dc.contributor.author Marcondes, Fernanda Klein
dc.date.accessioned 2020-07-08T13:09:35Z
dc.date.available 2020-07-08T13:09:35Z
dc.date.issued 2018
dc.identifier http://dx.doi.org/10.1016/j.steroids.2017.12.013
dc.identifier.citation Steroids. New York, v. 131, p. 41456, 2018.
dc.identifier.issn 0039-128X
dc.identifier.uri https://repositorio.unifesp.br/handle/11600/54081
dc.description.abstract Anabolic Androgenic Steroids (AASs) misuse has increased among adolescents and recreational athletes due to their potential effects on muscle hypertrophy. On the other hand, AAS might induce alterations on cardiovascular system, although some controversies regarding AAS on vascular properties remain unknown. To address this question, we aimed to investigate the effects of high doses of nandrolone combined with strenuous resistance training (RT) on function and structure of thoracic aorta. Rats were randomized into four groups: non-trained vehicle (NTV), trained vehicle (TV), non-trained nandrolone (NTN), and trained nandrolone (TN), and submitted to 6 weeks of treatment with nandrolone (5 mg/kg, twice a week) and/or resistance training. In vitro response of thoracic aorta to acetylcholine (ACh) was analyzed. Vascular nitric oxide (NO) and reactive oxygen species (ROS) synthesis were evaluated using 4,5-diaminofluorescein diacetate (DAF-2) and hydroethidine fluorescent techniques, respectively. Thoracic aorta was processed for microscopy analyses and tunica media thickness was measured. ACh-mediated relaxation response was impaired in endothelium intact aortic rings isolated from trained rats (TV and TN) as compared with their matched non-trained groups. TN rats showed reduced ACh-mediated vasodilatation than NTN rats. NO production and bioavailability decreased in thoracic aorta of nandrolone-treated rats in relation to their matched non-trained group (NTN vs. NW en
dc.description.abstract TN vs. TV). ROS production and tunica media thickness were increased in TN rats when compared with TV rats. These findings indicate that high doses of nandrolone combined with strenuous RT affect NO bioavailability and might induce endothelial dysfunction and arterial morphological alterations. en
dc.description.sponsorship Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
dc.format.extent jul/13
dc.language.iso eng
dc.publisher Elsevier Science Inc
dc.relation.ispartof Steroids
dc.rights Acesso restrito
dc.subject Nandrolone en
dc.subject Resistance training en
dc.subject Vasodilatation en
dc.subject Nitric oxide en
dc.subject Reactive oxygen species en
dc.title Nandrolone combined with strenuous resistance training reduces vascular nitric oxide bioavailability and impairs endothelium-dependent vasodilation en
dc.type Artigo
dc.description.affiliation Univ Campinas FOP UNICAMP, Piracicaba Dent Sch, Dept Oral Physiol, Piracicaba, SP, Brazil
dc.description.affiliation Univ Fed Sao Paulo, Sci & Technol Inst, Sao Jose Dos Campos, Brazil
dc.description.affiliation Pontifical Catholic Univ Campinas PUC, Fac Med Sci, Campinas, SP, Brazil
dc.description.affiliation Univ Fed Sao Paulo, Sch Med, Nephrol Div, Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Sci & Technol Inst, Sao Jose Dos Campos, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Sch Med, Nephrol Div, Sao Paulo, Brazil
dc.description.sponsorshipID FAPESP: 07/57380-9
dc.identifier.doi 10.1016/j.steroids.2017.12.013
dc.description.source Web of Science
dc.identifier.wos WOS:000425556100002
dc.coverage New York
dc.citation.volume 131



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