Consequences of continuous social defeat stress on anxiety- and depressive-like behaviors and ethanol reward in mice

Consequences of continuous social defeat stress on anxiety- and depressive-like behaviors and ethanol reward in mice

Author Macedo, Giovana Camila Autor UNIFESP Google Scholar
Morita, Gleice Midori Autor UNIFESP Google Scholar
Domingues, Liz Paola Autor UNIFESP Google Scholar
Favoretto, Cristiane Aparecida Autor UNIFESP Google Scholar
Suchecki, Deborah Autor UNIFESP Google Scholar
Hartmann Quadros, Isabel Marian Autor UNIFESP Google Scholar
Abstract This study employed the intruder-resident paradigm to evaluate the effects of continuous social defeat on depressive- and anxiety-like behaviors and the reinforcing and motivational actions of ethanol in male Swiss mice. Male Swiss mice were exposed to a 10-day social defeat protocol, while control mice cohabitated with a non aggressive animal. Continuous defeat stress consisted of episodes of defeat, followed by 24 h or 48 h cohabitation with the aggressor until the following defeat. Mice were assessed for sucrose drinking (anhedonia), social investigation test, elevated plus-maze, conditioned place preference to ethanol, and locomotor response to ethanol. Plasma corticosterone was measured prior to, after the first and the final defeat, and 10 days after the end of defeat. Defeated mice exhibited a depressive-like phenotype as indicated by social inhibition and reduced sucrose preference, relative to non-defeated controls. Defeated mice also displayed anxiety-like behavior when tested in the elevated plus-maze. Stressed animals failed to present ethanol-induced locomotor stimulation, but showed increased sensitivity for ethanol-induced conditioned place preference. Corticosterone response to defeat was the highest after the first defeat, but was still elevated after the last defeat (day 10) when compared to non stressed controls. Baseline corticosterone levels were unchanged 10 days after the final defeat. These data suggest that social defeat stress increased depressive- and anxiety-like behavior as well increased vulnerability to ethanol reward in mice.
Keywords Social stress
Social investigation
Elevated plus maze
Sucrose drinking
xmlui.dri2xhtml.METS-1.0.item-coverage San Diego
Language English
Sponsor FAPESP
Date 2018
Published in Hormones And Behavior. San Diego, v. 97, p. 154-161, 2018.
ISSN 0018-506X (Sherpa/Romeo, impact factor)
Publisher Academic Press Inc Elsevier Science
Extent 154-161
Access rights Closed access
Type Article
Web of Science ID WOS:000423419100021

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