H-1-NMR, H-1-NMR T-2-edited, and 2D-NMR in bipolar disorder metabolic profiling

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dc.contributor.author Sethi, Sumit [UNIFESP]
dc.contributor.author Pedrini, Mariana [UNIFESP]
dc.contributor.author Rizzo, Lucas B. [UNIFESP]
dc.contributor.author Zeni-Graiff, Maiara [UNIFESP]
dc.contributor.author Dal Mas, Caroline [UNIFESP]
dc.contributor.author Cassinelli, Ana Claudia
dc.contributor.author Noto, Mariane N. [UNIFESP]
dc.contributor.author Asevedo, Elson [UNIFESP]
dc.contributor.author Cordeiro, Quirino
dc.contributor.author Pontes, Joao G. M.
dc.contributor.author Brasil, Antonio J. M.
dc.contributor.author Lacerda, Acioly [UNIFESP]
dc.contributor.author Hayashi, Mirian A. F. [UNIFESP]
dc.contributor.author Poppi, Ronei
dc.contributor.author Tasic, Ljubica
dc.contributor.author Brietzke, Elisa [UNIFESP]
dc.date.accessioned 2020-06-26T16:30:37Z
dc.date.available 2020-06-26T16:30:37Z
dc.date.issued 2017
dc.identifier http://dx.doi.org/10.1186/s40345-017-0088-2 ]
dc.identifier.citation International Journal Of Bipolar Disorders. Heidelberg, v. 5, p. -, 2017.
dc.identifier.issn 2194-7511
dc.identifier.uri https://repositorio.unifesp.br/handle/11600/53670
dc.description.abstract Background: The objective of this study was to identify molecular alterations in the human blood serum related to bipolar disorder, using nuclear magnetic resonance (NMR) spectroscopy and chemometrics. Methods: Metabolomic profiling, employing H-1-NMR, H-1-NMR -T-2-edited, and 2D-NMR spectroscopy and chemometrics of human blood serum samples from patients with bipolar disorder (n = 26) compared with healthy volunteers (n = 50) was performed. Results: The investigated groups presented distinct metabolic profiles, in which the main differential metabolites found in the serum sample of bipolar disorder patients compared with those from controls were lipids, lipid metabolism-related molecules (choline, myo-inositol), and some amino acids (N-acetyl-L-phenyl alanine, N-acetyl-L-aspartyl-L-glutamic acid, L-glutamine). In addition, amygdalin, alpha-ketoglutaric acid, and lipoamide, among other compounds, were also present or were significantly altered in the serum of bipolar disorder patients. The data presented herein suggest that some of these metabolites differentially distributed between the groups studied may be directly related to the bipolar disorder pathophysiology. Conclusions: The strategy employed here showed significant potential for exploring pathophysiological features and molecular pathways involved in bipolar disorder. Thus, our findings may contribute to pave the way for future studies aiming at identifying important potential biomarkers for bipolar disorder diagnosis or progression follow-up. en
dc.description.sponsorship Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq, Brasilia, Brazil)
dc.description.sponsorship FAPESP
dc.format.extent -
dc.language.iso eng
dc.publisher Springer Heidelberg
dc.relation.ispartof International Journal Of Bipolar Disorders
dc.rights ACESSO ABERTO
dc.subject H-1-NMR en
dc.subject Biomarkers en
dc.subject Bipolar disorder en
dc.subject Metabolic profiling en
dc.subject Chemometrics en
dc.subject 2D NMR en
dc.title H-1-NMR, H-1-NMR T-2-edited, and 2D-NMR in bipolar disorder metabolic profiling en
dc.type Artigo
dc.description.affiliation Univ Fed Sao Paulo UNIFESP, Dept Psychiat, Rua Borges Lagoa 570, BR-04038020 Sao Paulo, Brazil
dc.description.affiliation Univ Fed Sao Paulo UNIFESP, Dept Pharmacol, Rua Tres Maio 100, BR-04044020 Sao Paulo, Brazil
dc.description.affiliation ISCMSP, Dept Psychiat, Rua Major Maragliano 287, BR-04017030 Sao Paulo, Brazil
dc.description.affiliation Univ Estadual Campinas UNICAMP, Lab Quim Biol, Dept Organ Chem, Inst Chem, Caixa Postal 6154, BR-13083970 Sao Paulo, Brazil
dc.description.affiliation Univ Estadual Campinas UNICAMP, Dept Analyt Chem, Inst Chem, Caixa Postal 6154, BR-13083970 Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo UNIFESP, Dept Psychiat, Rua Borges Lagoa 570, BR-04038020 Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo UNIFESP, Dept Pharmacol, Rua Tres Maio 100, BR-04044020 Sao Paulo, Brazil
dc.description.sponsorshipID CNPq
dc.description.sponsorshipID FAPESP: 2014/18938-8
dc.identifier.file WOS000403186100001.pdf
dc.identifier.doi 10.1186/s40345-017-0088-2
dc.description.source Web of Science
dc.identifier.wos WOS:000403186100001
dc.coverage Heidelberg
dc.citation.volume 5 ]



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