Fish Oil Supplementation Reduces Heart Levels of Interleukin-6 in Rats with Chronic Inflammation due to Epilepsy

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Nejm, Mariana Bocca [UNIFESP]
Abou Haidar, Andre [UNIFESP]
Hirata, Aparecida Emiko [UNIFESP]
Oyama, Lila Missae [UNIFESP]
de Almeida, Antonio-Carlos Guimaraes
Cysneiros, Roberta Monterazzo
Cavalheiro, Esper Abrao [UNIFESP]
Scorza, Carla Alessandra [UNIFESP]
Scorza, Fulvio Alexandre [UNIFESP]
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Sudden unexpected death in epilepsy (SUDEP) is a major cause of premature death related to epilepsy. The causes of SUDEP remain unknown, but cardiac arrhythmias and asphyxia have been suggested as a major mechanism of this event. Inflammation has been implicated in the pathogenesis of both epilepsy and ventricular arrhythmia, with interleukin-6 (IL-6) being recognized as a crucial orchestrator of inflammatory states. Our group previously reported that levels of IL-6 were increased in the hearts of epileptic rats. In this scenario, anti-inflammatory actions are among the beneficial effects of fish oil dietary supplementation. This investigation revealed that elevated levels of IL-6 in the heart were markedly reduced in epileptic rats that were treated in the long-term with fish oil, suggesting protective anti-inflammatory actions against dangerously high levels of IL-6. Based on these findings, our results suggest beneficial effects of long-term intake of fish oil in reducing the inflammation associated with chronic epilepsy.
Frontiers In Neurology. Lausanne, v. 8, p. -, 2017.