Combination of a high-fat diet with sweetened condensed milk exacerbates inflammation and insulin resistance induced by each separately in mice

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dc.contributor.author Masi, Laureane Nunes
dc.contributor.author Martins, Amanda Roque
dc.contributor.author Crisma, Amanda Rabello
dc.contributor.author do Amaral, Catia Lira
dc.contributor.author Davanso, Mariana Rodrigues
dc.contributor.author Afonso Serdan, Tamires Duarte
dc.contributor.author Cavalcante da Cunha de Sa, Roberta Dourado [UNIFESP]
dc.contributor.author Cruz, Maysa Mariana [UNIFESP]
dc.contributor.author Cardoso Alonso-Vale, Maria Isabel [UNIFESP]
dc.contributor.author Torres, Rosngela Pavan
dc.contributor.author Mancini-Filho, Jorge
dc.contributor.author Bertaglia Pereira, Joice Naiara
dc.contributor.author da Silva Righetti, Marta Maria
dc.contributor.author Liberti, Edson Aparecido
dc.contributor.author Hirabara, Sandro Massao
dc.contributor.author Curi, Rui
dc.date.accessioned 2020-06-26T16:30:35Z
dc.date.available 2020-06-26T16:30:35Z
dc.date.issued 2017
dc.identifier http://dx.doi.org/10.1038/s41598-017-04308-1 ]
dc.identifier.citation Scientific Reports. London, v. 7, p. -, 2017.
dc.identifier.issn 2045-2322
dc.identifier.uri https://repositorio.unifesp.br/handle/11600/53643
dc.description.abstract Obesogenic diets increase body weight and cause insulin resistance (IR), however, the association of these changes with the main macronutrient in the diet remains to be elucidated. Male C57BL/6 mice were fed with: control (CD), CD and sweetened condensed milk (HS), high-fat (HF), and HF and condensed milk (HSHF). After 2 months, increased body weight, glucose intolerance, adipocyte size and cholesterol levels were observed. As compared with CD, HS ingested the same amount of calories whereas HF and HSHF ingested less. HS had increased plasma AST activity and liver type I collagen. HF caused mild liver steatosis and hepatocellular damage. HF and HSHF increased LDL-cholesterol, hepatocyte and adipocyte hypertrophy, TNF-alpha by macrophages and decreased lipogenesis and adiponectin in adipose tissue (AT). HSHF exacerbated these effects, increasing IR, lipolysis, mRNA expression of F4/80 and leptin in AT, Tlr-4 in soleus muscle and IL-6, IL-1 beta, VCAM-1, and ICAM-1 protein in AT. The three obesogenic diets induced obesity and metabolic dysfunction. HS was more proinflammatory than the HF and induced hepatic fibrosis. The HF was more detrimental in terms of insulin sensitivity, and it caused liver steatosis. The combination HSHF exacerbated the effects of each separately on insulin resistance and AT inflammatory state. en
dc.description.sponsorship CAPES
dc.description.sponsorship CNPq
dc.description.sponsorship FAPESP
dc.description.sponsorship Guggenheim Foundation
dc.format.extent -
dc.language.iso eng
dc.publisher Nature Publishing Group
dc.relation.ispartof Scientific Reports
dc.rights ACESSO ABERTO
dc.title Combination of a high-fat diet with sweetened condensed milk exacerbates inflammation and insulin resistance induced by each separately in mice en
dc.type Artigo
dc.description.affiliation Univ Cruzeiro Sul, Interdisciplinary Postgrad Program Hlth Sci, Sao Paulo, Brazil
dc.description.affiliation Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo, Brazil
dc.description.affiliation State Univ Goias, Campus Exact Sci & Technol, Anapolis, Brazil
dc.description.affiliation Univ Fed Sao Paulo, Inst Biomed Sci, Dept Biol Sci, Sao Paulo, Brazil
dc.description.affiliation Univ Sao Paulo, Fac Pharmaceut Sci, Dept Food & Expt Nutr, Sao Paulo, Brazil
dc.description.affiliation Univ Sao Paulo, Inst Biomed Sci, Dept Anat, Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Inst Biomed Sci, Dept Biol Sci, Sao Paulo, Brazil
dc.description.sponsorshipID CAPES
dc.description.sponsorshipID CNPq
dc.description.sponsorshipID FAPESP
dc.description.sponsorshipID Guggenheim Foundation
dc.identifier.file WOS000403840000009.pdf
dc.identifier.doi 10.1038/s41598-017-04308-1
dc.description.source Web of Science
dc.identifier.wos WOS:000403840000009
dc.coverage London
dc.citation.volume 7 ]



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