Metabolomics and lipidomics analyses by H-1 nuclear magnetic resonance of schizophrenia patient serum reveal potential peripheral biomarkers for diagnosis

Show simple item record

dc.contributor.author Tasic, Ljubica
dc.contributor.author Pontes, Joao G. M.
dc.contributor.author Carvalho, Michelle S. [UNIFESP]
dc.contributor.author Cruz, Guilherme
dc.contributor.author Dal Mas, Carolines [UNIFESP]
dc.contributor.author Sethi, Sumit [UNIFESP]
dc.contributor.author Pedrini, Mariana [UNIFESP]
dc.contributor.author Rizzo, Lucas B. [UNIFESP]
dc.contributor.author Zeni-Graiff, Maiara [UNIFESP
dc.contributor.author Asevedo, Elson [UNIFESP]
dc.contributor.author Lacerda, Acioly L. T. [UNIFESP]
dc.contributor.author Bressan, Rodrigo A. [UNIFESP]
dc.contributor.author Poppi, Ronei Jesus
dc.contributor.author Brietzke, Elisa [UNIFESP]
dc.contributor.author Hayashi, Mirian A. F. [UNIFESP]
dc.date.accessioned 2020-06-26T16:30:33Z
dc.date.available 2020-06-26T16:30:33Z
dc.date.issued 2017
dc.identifier http://dx.doi.org/10.1016/j.schres.2016.12.024 ]
dc.identifier.citation Schizophrenia Research. Amsterdam, v. 185, p. 182-189, 2017.
dc.identifier.issn 0920-9964
dc.identifier.uri https://repositorio.unifesp.br/handle/11600/53619
dc.description.abstract Using H-1 NMR-based metabolomics in association to chemometrics analysis, we analyzed here the metabolic differences between schizophrenia patients (SCZ) compared to healthy controls (HCs). HCs and SCZ patients underwent clinical interview using the Structured Clinical Interview for DSM Disorders (SCID). SCZ patients were further assessed by Positive and Negative Syndrome Scale (PANSS), Calgary Depression Scale, Global Assessment of Functioning Scale (GAF), and Clinical Global Impressions Scale (CGI). Using the principal component analysis (PCA) and supervised partial least-squares discriminate analysis (PLS-DA) in obtained NMR data, a clear group separation between HCs and SCZ patients was achieved. Interestingly, all metabolite compounds identified as exclusively present in the SCZ group, except for the gamma-aminobutyric acid (GABA), were never previously associated with mental disorders. Although the initial perception of an absence of obvious biological link among the different key molecules exclusively observed in each group, and no identification of any specific pathway yet, the present work represents an important contribution for the identification of potential biomarkers to inform diagnosis, as it was possible to completely separate the affected SCZ patients from HCs, with no outliers or exceptions. In addition, the data presented here reinforced the role of the modulation of glycolysis pathway and the loss of GABA intemeuron/hyperglutamate hypothesis in SCZ. (C) 2016 Elsevier B.V. All rights reserved. en
dc.description.sponsorship Sao Paulo Research Foundation (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
dc.description.sponsorship National Council of Technological and Scientific Development (CNPq)
dc.description.sponsorship Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
dc.format.extent 182-189
dc.language.iso eng
dc.publisher Elsevier Science Bv
dc.relation.ispartof Schizophrenia Research
dc.rights ACESSO RESTRITO
dc.subject Schizophrenia en
dc.subject Psychosis en
dc.subject Biomarkers en
dc.subject Serum en
dc.subject NMR en
dc.subject Lipidomics en
dc.subject Metabolomics en
dc.title Metabolomics and lipidomics analyses by H-1 nuclear magnetic resonance of schizophrenia patient serum reveal potential peripheral biomarkers for diagnosis en
dc.type Artigo
dc.description.affiliation Univ Estadual Campinas UNICAMP, Inst Chem, Dept Organ Chem, Campinas, SP, Brazil
dc.description.affiliation Univ Fed Sao Paulo UNIFESP, Integrated Lab Clin Neurosci LiNC, Sao Paulo, Brazil
dc.description.affiliation Univ Fed Sao Paulo UNIFESP, Schizophrenia Program PROESQ, Dept Psychiat, Sao Paulo, Brazil
dc.description.affiliation Univ Fed Sao Paulo UNIFESP, Dept Pharmacol, Sao Paulo, Brazil
dc.description.affiliation Univ Fed Sao Paulo UNIFESP, Dept Psychiat, Sao Paulo, Brazil
dc.description.affiliation Univ Estadual Campinas UNICAMP, Inst Chem, Dept Analyt Chem, Campinas, SP, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo UNIFESP, Integrated Lab Clin Neurosci LiNC, Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo UNIFESP, Schizophrenia Program PROESQ, Dept Psychiat, Sao Paulo, Brazill
dc.description.affiliationUnifesp Univ Fed Sao Paulo UNIFESP, Dept Pharmacol, Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo UNIFESP, Dept Psychiat, Sao Paulo, Brazil
dc.description.sponsorshipID FAPESP: 2014/18938-8
dc.description.sponsorshipID FAPESP: 2013/13392-4
dc.description.sponsorshipID CNPq: 477760/2010-4
dc.description.sponsorshipID CNPq: 557753/2010-4
dc.description.sponsorshipID CNPq: 508113/2010-5
dc.description.sponsorshipID CNPq: 311815/2012-0
dc.description.sponsorshipID CNPq: 475739/2013-2
dc.description.sponsorshipID CNPq: 454234/2014-7
dc.description.sponsorshipID CAPES
dc.identifier.doi 10.1016/j.schres.2016.12.024
dc.description.source Web of Science
dc.identifier.wos WOS:000403561000026
dc.coverage Amsterdam
dc.citation.volume 185 ]



File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search


Browse

Statistics

My Account