Transplante Autólogo De Células Tronco Hematopoiéticas Periféricas Com A Presença De Neuroblastos Citodiferenciados Na Medula Óssea, Ao Final Da Terapia De Indução, Em Crianças Com Neuroblastoma Estádio 4
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Data
2018-04-26
Autores
Jacob, Marcella Baggiani Antonelli [UNIFESP]
Orientadores
Caran, Eliana Maria Monteiro [UNIFESP]
Tipo
Dissertação de mestrado
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Resumo
Background: The Major Metastatic Site Of Neuroblastoma Is The Bone Marrow, In These Cases De Long-Term Survival Is Less Than 50%. Therapeutic Consolidation Is Performed With Myeloablative Therapy Followed By Autologous Transplantation And Improves The Outcome. Classically, The Opportunity To Perform The Consolidation Treatment Is Restricted To Cases In Which The Bone Marrow Does Not Show Metastatic Cells, Including Differentiating Neuroblast, At The End Of The Induction. However, The Presence Of Differentiated Neuroblasts In The Bone Marrow Would Be An Impediment To The Collection Of Peripheral Stem Cells In Patients With Neuroblastoma? Purpose: Characterize The Epidemiological Profile And Survival Of Patients With High-Risk Neuroblastoma Who Had Bone Marrow Involvement At Diagnostic, With Emphasis On Patients With Differentiating Neuroblast In The Bone Marrow That Precedes Transplantation. Methods: Retrospective Analysis Of Patients With High-Risk Neuroblastoma Who Had Bone Marrow Involvement At Diagnostic A
Background: The Major Metastatic Site Of Neuroblastoma Is The Bone Marrow, In These Cases De Long-Term Survival Is Less Than 50%. Therapeutic Consolidation Is Performed With Myeloablative Therapy Followed By Autologous Transplantation And Improves The Outcome. Classically, The Opportunity To Perform The Consolidation Treatment Is Restricted To Cases In Which The Bone Marrow Does Not Show Metastatic Cells, Including Differentiating Neuroblast, At The End Of The Induction. However, The Presence Of Differentiated Neuroblasts In The Bone Marrow Would Be An Impediment To The Collection Of Peripheral Stem Cells In Patients With Neuroblastoma? Purpose: Characterize The Epidemiological Profile And Survival Of Patients With High-Risk Neuroblastoma Who Had Bone Marrow Involvement At Diagnostic, With Emphasis On Patients With Differentiating Neuroblast In The Bone Marrow That Precedes Transplantation. Methods: Retrospective Analysis Of Patients With High-Risk Neuroblastoma Who Had Bone Marrow Involvement At Diagnostic A
Background: The Major Metastatic Site Of Neuroblastoma Is The Bone Marrow, In These Cases De Long-Term Survival Is Less Than 50%. Therapeutic Consolidation Is Performed With Myeloablative Therapy Followed By Autologous Transplantation And Improves The Outcome. Classically, The Opportunity To Perform The Consolidation Treatment Is Restricted To Cases In Which The Bone Marrow Does Not Show Metastatic Cells, Including Differentiating Neuroblast, At The End Of The Induction. However, The Presence Of Differentiated Neuroblasts In The Bone Marrow Would Be An Impediment To The Collection Of Peripheral Stem Cells In Patients With Neuroblastoma? Purpose: Characterize The Epidemiological Profile And Survival Of Patients With High-Risk Neuroblastoma Who Had Bone Marrow Involvement At Diagnostic, With Emphasis On Patients With Differentiating Neuroblast In The Bone Marrow That Precedes Transplantation. Methods: Retrospective Analysis Of Patients With High-Risk Neuroblastoma Who Had Bone Marrow Involvement At Diagnostic A