Plasma copeptin and metabolic dysfunction in individuals with bipolar disorder

Plasma copeptin and metabolic dysfunction in individuals with bipolar disorder

Author Mansur, Rodrigo B. Autor UNIFESP Google Scholar
Rizzo, Lucas B. Autor UNIFESP Google Scholar
Santos, Camila M. Autor UNIFESP Google Scholar
Asevedo, Elson Autor UNIFESP Google Scholar
Cunha, Graccielle R. Autor UNIFESP Google Scholar
Noto, Mariane N. Autor UNIFESP Google Scholar
Pedrini, Mariana Autor UNIFESP Google Scholar
Zeni-Graiff, Maiara Autor UNIFESP Google Scholar
Cordeiro, Quirino Google Scholar
McIntyre, Roger S. Google Scholar
Brietzke, Elisa Autor UNIFESP Google Scholar
Abstract AimThis study aimed to compare plasma copeptin levels, the c-terminal of provasopressin, between individuals with bipolar disorder (BD) and healthy controls and to assess the relation between copeptin and metabolic parameters. MethodsWe measured plasma levels of copeptin in individuals with BD (n=55) and healthy controls (n=21). Information related to psychiatric/medical history, as well as to metabolic comorbidities and laboratorial parameters was also captured. Insulin resistance and -cell function in basal state were calculated from fasting plasma glucose and C-peptide using the HOMA2 calculator. Impaired glucose metabolism was defined as pre-diabetes or type 2 diabetes mellitus. Copeptin, adiponectin, and leptin plasma levels were determined by enzyme-linked immunosorbent assay. ResultsPlasma copeptin levels were lower in individuals with BD, relative to healthy controls (P<0.001). There were significant interactions between BD and plasma copeptin on -cell function (rate ratio [RR]=1.048

P=0.030) and on leptin levels (RR=1.087

P=0.012), indicating that there was a positive correlation between these markers in the BD group, but a negative one in healthy controls. Finally, in individuals with BD only, the association between -cell function, body mass index (RR=1.007

P<0.001), and insulin resistance (RR=1.001

P=0.037) was moderated by copeptin levels. ConclusionCopeptin levels were lower in individuals with BD than in healthy controls. There were differential associations between copeptin and metabolic parameters within the BD and healthy control subgroups, suggesting an association between abnormal copeptin and metabolic dysregulation only in the BD population.
Keywords bipolar disorder
insulin resistance
Language English
Sponsor Sao Paulo Research Foundation (FAPESP)
Date 2017
Published in Psychiatry And Clinical Neurosciences. Hoboken, v. 71, n. 9, p. 624-636, 2017.
ISSN 1323-1316 (Sherpa/Romeo, impact factor)
Publisher Wiley
Extent 624-636
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000409188900004

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