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dc.contributor.authorTim, Carla Roberta [UNIFESP]
dc.contributor.authorBossini, Paulo Sergio [UNIFESP]
dc.contributor.authorKido, Hueliton Wilian [UNIFESP]
dc.contributor.authorMalavazi, Iran
dc.contributor.authorvon Zeska Kress, Marcia Regina
dc.contributor.authorCarazzolle, Marcelo Falsarella
dc.contributor.authorRenno, Ana Claudia Muniz [UNIFESP]
dc.contributor.authorParizotto, Nivaldo Antonio
dc.identifier.citationJournal Of Biomedical Optics. Bellingham, v. 21, n. 8, p. -, 2016.
dc.description.abstractThis study investigates the histological modifications produced by low level laser therapy (LLLT) on the first day of bone repair, as well as evaluates the LLLT effects on collagen expression on the site of a fracture. Twenty Wistar rats were distributed into a control group (CG) and a laser group (LG). Laser irradiation of Ga-AlAs laser 830 nm, 30 mW, 94 s, 2.8 J was performed in five sessions. Animals were euthanized on day 5 post-surgery. Histopathological analysis showed that LLLT was able to increase deposition of granulation tissue and newly formed bone at the site of the injury. In addition, picrosirius analysis showed that collagen fiber organization in the LG was enhanced compared to CG. Microarray analysis demonstrated that LLLT produced an upregulation type I collagen (COL-I). Immunohistochemical analysis revealed that the subjects that were treated presented a higher immunoexpression of COL-I. Our findings indicated that LLLT improves bone healing by producing a significant increase in the expression of collagen genes. (C) 2016 Society of Photo-Optical Instrumentation Engineers (SPIE)en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCenter for Computational Engineering and Sciences at UNICAMP SP Brazil (FAPESP/CEPID) [2013/08293-7]
dc.publisherSpie-Soc Photo-Optical Instrumentation Engineers
dc.rightsAcesso restrito
dc.subjectBone regenerationen
dc.subjectLow level laser therapyen
dc.titleLow-level laser therapy induces an upregulation of collagen gene expression during the initial process of bone healing: a microarray analysisen
dc.description.affiliationUniv Fed Sao Paulo, Dept Biosci, Ave Ana Costa 95, BR-11050240 Santos, Brazil
dc.description.affiliationUniv Fed Sao Carlos, Dept Genet & Evolut, Rod Washington Luis Km 235, BR-13565905 Sao Carlos, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Dept Clin Anal Toxicol & Bromatol, Ave Cafe 95, BR-14049900 Ribeirao Preto, Brazil
dc.description.affiliationUniv Estadual Campinas, Dept Genet & Evolut, BR-13083970 Campinas, SP, Brazil
dc.description.affiliationBrazilian Natl Ctr Res Energy & Mat, Brazilian Biosci Natl Lab, Giuseppe Maximo Scolfaro 10-000, BR-13083970 Campinas, SP, Brazil
dc.description.affiliationUniv Fed Sao Carlos, Dept Physiotherapy, Rod Washington Luis Km 235, BR-13565905 Sao Carlos, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Biosci, Ave Ana Costa 95, BR-11050240 Santos, Brazil
dc.description.sourceWeb of Science

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