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dc.contributor.authorDal Molin Netto, Bárbara [UNIFESP]
dc.contributor.authorEarthman, Carrie P.
dc.contributor.authorBettini, Solange Cravo
dc.contributor.authorClemente, Ana Paula Grotti [UNIFESP]
dc.contributor.authorMasquio, Deborah Cristina Landi [UNIFESP]
dc.contributor.authorFarias, Gisele
dc.contributor.authorBoritza, Katia
dc.contributor.authorSilva, Larissa Gabrielle da
dc.contributor.authorvon der Heyde, Maria Emilia
dc.contributor.authorDâmaso, Ana Raimunda [UNIFESP]
dc.identifier.citationEuropean Journal Of Gastroenterology & Hepatology. Philadelphia, v. 28, n. 9, p. 1050-1055, 2016.
dc.description.abstractIntroduction Body weight varies depending on the prevailing direction of environmental pressuresen
dc.description.abstracthowever, physiological factors also play a significant role in the control of body weight. The aim of the present study was to assess the impact of Roux-en-Y gastric bypass (RYGB) on hormones and peptides involved in the control of energy balance and their possible implications in appetite/satiety. Methods The sample included 39 individuals with extreme obesity (37 women and two men) who underwent RYGB. Anthropometric and biochemical markers were collected before surgery and 6 months after RYGB. Results The BMI decreased from 44.3 +/- 6.4 to 31.7 +/- 5.7 kg/m(2) (P<0.001) at the sixth month. Percentage of excess weight lost was 63.2 +/- 25.0%. Leptin and glucose levels decreased significantly 6 months after RYGB (P<0.001). Interestingly, a significant correlation was confirmed between the anorexigenic gut hormone peptide YY (PYY) and the central anorexigenic mediator alpha-melanocyte-stimulating hormone after 6 months of RYGB (r=0.35, P=0.004). In contrast, PYY concentrations were correlated negatively with BMI (r=-0.34, P=0.002). Conclusion In the present investigation, it was found that there is a relationship between a-melanocyte-stimulating hormone and PYY concentrations, and it supports the role of the PYY to POMC signal in appetite regulation after RYGB. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.publisherLippincott Williams & Wilkins
dc.rightsAcesso restrito
dc.subjectEnergy regulationen
dc.subjectGastric bypassen
dc.subjectGastrointestinal hormonesen
dc.titleEarly effects of Roux-en-Y gastric bypass on peptides and hormones involved in the control of energy balanceen
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, UNIFESP EPM, Post Grad Program Nutr, Sao Paulo, Brazil
dc.description.affiliationFed Univ Parana UFPR, Bariatr Surg Serv, Curitiba, Parana, Brazil
dc.description.affiliationFed Univ Parana UFPR, Biochem Sect, Hosp Clin, Curitiba, Parana, Brazil
dc.description.affiliationFed Univ Parana UFPR, Dept Nutr, Curitiba, Parana, Brazil
dc.description.affiliationFed Univ Parana UFPR, Grad Nutr, Curitiba, Parana, Brazil
dc.description.affiliationUniv Minnesota Twin Cities, Dept Food Sci & Nutr, Minneapolis, MN USA
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, UNIFESP EPM, Post Grad Program Nutr, Sao Paulo, Brazil
dc.description.sponsorshipIDCAPES: 2262/14-2
dc.description.sponsorshipIDCAPES: 2566/2011
dc.description.sourceWeb of Science

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