Association of serum interleukin-6 with mental health problems in children exposed to perinatal complications and social disadvantage

Association of serum interleukin-6 with mental health problems in children exposed to perinatal complications and social disadvantage

Author Mansur, Rodrigo B. Autor UNIFESP Google Scholar
Cunha, Graccielle R. Autor UNIFESP Google Scholar
Asevedo, Elson Autor UNIFESP Google Scholar
Zugman, Andre Autor UNIFESP Google Scholar
Rizzo, Lucas B. Autor UNIFESP Google Scholar
Grassi-Oliveira, Rodrigo Google Scholar
Levandowski, Mateus L. Google Scholar
Gadelha, Ary Autor UNIFESP Google Scholar
Pan, Pedro M. Autor UNIFESP Google Scholar
Teixeira, Antonio L. Google Scholar
McIntyre, Roger S. Google Scholar
Mari, Jair J. Autor UNIFESP Google Scholar
Rohde, Luis A. Google Scholar
Miguel, Euripedes C. Google Scholar
Bressan, Rodrigo A. Autor UNIFESP Google Scholar
Brietzke, Elisa Autor UNIFESP Google Scholar
Abstract There is consistent evidence that inflammation is involved in mental disorders pathogenesis. Herein, using data from the High Risk Cohort Study for Psychiatric Disorders, we investigated the relationship between parental mood disorders (PMD), environmental factors, serum interleuldn-6 (IL6) and mental health problems in children aged 6-12. We measured the serum levels of IL6 in 567 children. Information related to socio-demographic characteristics, mental health problems and multiple risk factors, as well as parent's psychiatric diagnosis, was captured. We evaluated two groups of environmental risk factors (i.e. perinatal complications and social disadvantage) using a cumulative risk model. Results showed that higher serum levels of IL6 were associated with PMD (RR = 1.072, p = 0.001), perinatal complications (RR = 1.022, p = 0.013) and social disadvantage (RR = 1.024, p = 0.021). There was an interaction between PMD and social disadvantage (RR = 1.141, p = 0.021), as the effect of PMD on 16 was significantly higher in children exposed to higher levels of social disadvantage. Moreover, there was a positive correlation between IL6 and mental health problems (RR = 1.099, p = 0.026), which was moderated by exposure to perinatal complications or social disadvantage (RR = 1.273, p = 0.015 and RR = 1.179, p = 0.048, respectively). In conclusions, there is evidence of a differential inflammatory activation in children with PMD and exposure to environmental risk factors, when compared to matched peers. Systemic inflammation may be involved in the pathway linking familial risk and mental health problems. (C) 2016 Elsevier Ltd. All rights
Keywords Familial mood disorder
Perinatal complications
Social disadvantage
Mental health problems
Language English
Sponsor National Council for Scientific and Technological Development (CNPq)
Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
Sao Paulo Research Foundation (FAPESP)
Date 2016
Published in Psychoneuroendocrinology. Oxford, v. 71, p. 94-101, 2016.
ISSN 0306-4530 (Sherpa/Romeo, impact factor)
Publisher Pergamon-Elsevier Science Ltd
Extent 94-101
Access rights Closed access
Type Article
Web of Science ID WOS:000381163000012

Show full item record


File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)




My Account