Rapid Eye Movement Sleep Behavior Disorder in Paraneoplastic Cerebellar Degeneration: Improvement with Immunotherapy
Vale, Thiago Cardoso
Fernandes do Prado, Lucila Bizari [UNIFESP]
do Prado, Gilmar Fernandes [UNIFESP]
Povoas Barsottini, Orlando Graziani [UNIFESP]
Pedroso, Jose Luiz [UNIFESP]
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Study Objectives: To report two female patients with paraneoplastic cerebellar degeneration (PCD) related to breast cancer that presented with rapid eye movement-sleep behavior disorder (RBD) and improved sleep symptoms with immunotherapy. Methods: The two patients were evaluated through clinical scale and polysomnography before and after therapy with intravenous immunoglobulin. Results: RBD was successfully treated with immunotherapy in both patients. Score on the RBD screening questionnaire dropped from 10 to 1 or 0, allied with the normalization of polysomnographic findings. Conclusions: A marked improvement in RBD after immunotherapy in PCD raises the hypothesis that secondary RBD may be an immune-mediated sleep disorder.
CitationSleep. Westchester, v. 39, n. 1, p. 117-120, 2016.
paraneoplastic cerebellar degeneration
REM-sleep behavior disorderRem-Sleep
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