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Alkaloids from croton echinocarpus baill.: Anti-hiv potential

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Date
2016
Author
Ravanelli, N.
Santos, Kátia P.
Motta, Lucimar Barbosa da
Lago, Joao Henrique Ghilardi [UNIFESP]
Furlan, Cláudia Maria
Type
Artigo
ISSN
0254-6299
Is part of
South African Journal Of Botany
DOI
10.1016/j.sajb.2015.06.011
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Abstract
Croton belongs to the Euphorbiaceae genus, one of the major Angiosperms families, and is widely distributed throughout the world, especially in the tropics. In this study, the hydroalcoholic extract (70% EtOH) of Croton echinocarpus leaves afforded two alkaloids: corydine and norisoboldine, and their structures were established by spectroscopic data interpretation (UV, IR, NMR and LREIMS). Both alkaloids displayed significant in vitro anti-HIV potential, inhibiting 40% of the HIV-1 reverse transcriptase enzyme activity at a concentration of 100 mu g mL(-1) of norisoboldine and 450 mu g mL(-1) of corydine. Corydine showed IC50 of 356.8 mu g mL(-1), while norisoboldine was more efficient on inhibiting the RT activity, showing IC50 of 153.7 mu g mL(-1). (C) 2015 SAAB. Published by Elsevier B.V. All rights reserved.
Citation
South African Journal Of Botany. Amsterdam, v. 102, p. 153-156, 2016.
Keywords
Norisoboldine
Corydine
Croton
Anti-Hiv ActivityDragons Blood
Molecular Phylogenetics
Euphorbiaceae
Extracts
Identification
Constituents
Urucurana
Plants
Sponsorship
Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [FAPESP 2012/10079-0]
Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
URI
http://repositorio.unifesp.br/handle/11600/49647
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  • ICAQF - Artigos [1140]

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