Alkaloids from croton echinocarpus baill.: Anti-hiv potential

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2016
Autores
Ravanelli, N.
Santos, Kátia P.
Motta, Lucimar Barbosa da
Lago, Joao Henrique Ghilardi [UNIFESP]
Furlan, Cláudia Maria
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Croton belongs to the Euphorbiaceae genus, one of the major Angiosperms families, and is widely distributed throughout the world, especially in the tropics. In this study, the hydroalcoholic extract (70% EtOH) of Croton echinocarpus leaves afforded two alkaloids: corydine and norisoboldine, and their structures were established by spectroscopic data interpretation (UV, IR, NMR and LREIMS). Both alkaloids displayed significant in vitro anti-HIV potential, inhibiting 40% of the HIV-1 reverse transcriptase enzyme activity at a concentration of 100 mu g mL(-1) of norisoboldine and 450 mu g mL(-1) of corydine. Corydine showed IC50 of 356.8 mu g mL(-1), while norisoboldine was more efficient on inhibiting the RT activity, showing IC50 of 153.7 mu g mL(-1). (C) 2015 SAAB. Published by Elsevier B.V. All rights reserved.
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South African Journal Of Botany. Amsterdam, v. 102, p. 153-156, 2016.
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