Effect of folic acid in a modified experimental model of anorectal malformations adriamycin-induced in rats

Date
2016Author
Fiorindo Faria, Danilo Jose [UNIFESP]
Simoes, Manuel de Jesus [UNIFESP]
Teixeira, Luciana Cristina [UNIFESP]
Pinheiro Faria, Angela Tucci
Simoes Ulhoa Cintra, Alvaro Edmundo [UNIFESP]
Martins, Jose Luiz [UNIFESP]
Type
ArtigoISSN
0102-8650Is part of
Acta Cirurgica BrasileiraDOI
10.1590/S0102-865020160010000004Metadata
Show full item recordAbstract
PURPOSE: To determine the effect of a single dose of adriamycin (ADR) to induce anorectal malformations (ARMs) and determine the effect of folic acid (FA) in this model. METHODS: Ten female Wistar rats were divided randomly in two groups. Group A - ADR Group B - FA+ADR. Dams from group B received daily, since two weeks before the pregnancy to the end of pregnancy, FA (50mg/kg) by gavage. Dams from both groups received ADR (6mk/kg) by intraperitoneal injection on gestational day (GD) 8. Their fetuses were harvested by cesarean section on GD21 and were examined looking for ARMs. The thickness of anal stratified squamous epithelium (ASSE) and intestinal epithelium (IE) were analyzed. p <= 0.05*. RESULTS: 81 fetuses were harvested. The number of fetuses number of ARMs mean (Delta%) (+/- SD) were determined to be, respectively: ADR -41[29 65%(+/- 37%)] versus FA+ADR - 40[04 16%(+/- 36%)] (p=0.05). AMRs were significantly lower in FA+ADR group than in ADR group (p=0.05). The thickness (mu m) of ASSE (+/- SD) and IE (+/- SD) were measured, respectively: ADR -[25.98(+/- 0.74) and 19.48(+/- 1.68)] versus FA+ADR -[24.74(+/- 0.91) and 24.80(+/- 0.81)] (p<0.005). The thickness of IE was significantly enlarged when FA was given (p<0.005). CONCLUSIONS: Single dose of adriamycin on D8 was able to induce anorectal malformations. Folic acid reduces the number and enlarged the IE of ARMs ADR-induced.
Citation
Acta Cirurgica Brasileira. Sao paulo, v. 31, n. 1, p. 22-27, 2016.Keywords
Anal CanalAnus
Imperforate
Doxorubicin
Folic Acid
RatsNeural-Tube Defects
Embryonic-Development
Hindgut Development
Mouse Model
Supplementation
Notochord
Ethylenethiourea
Expression
Pregnancy
Anomalies
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- EPM - Artigos [17709]
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