Current advances in targeted therapies for metastatic gastric cancer: improving patient care
Aguiar, Pedro Nazareth, Jr. [UNIFESP]
Muniz, Thiago Pimentel [UNIFESP]
Miranda, Raelson Rodrigues [UNIFESP]
Tadokoro, Hakaru [UNIFESP]
Forones, Nora Manoukian [UNIFESP]
Janjigian, Yelena Y.
de Mello, Ramon Andrade
Is part ofFuture Oncology
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In this article, we review the literature on the current advances in targeted therapies for metastatic gastric cancer aimed at improving patient care. We conclude that the key to guiding targeted therapy is individual biomarkers, which are not completely elucidated. HER2 overexpression is the only predictive biomarker currently in use. Furthermore, it is necessary to understand that gastric tumors are heterogeneoustherefore, is impossible to evaluate a novel biological compound without evaluating personal biomarkers. The selection of patients who are able to receive each treatment is paramount for improving advanced gastric cancer survival and reducing unnecessary costs.
CitationFuture Oncology. London, v. 12, n. 6, p. 839-854, 2016.
Gastric Cancer Therapy
Targeted TherapyAdvanced Esophagogastric Cancer
Gastroesophageal Junction Cancer
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