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dc.contributor.authorNery-Aguiar, Afif Rieth
dc.contributor.authorAguiar, Yousef Qathaf
dc.contributor.authorConde Junior, Airton Mendes
dc.contributor.authorAlencar, Airlane Pereira
dc.contributor.authorTavares, Cleciton Braga
dc.contributor.authorLopes-Costa, Pedro Vitor
dc.contributor.authorNazario, Afonso Celso [UNIFESP]
dc.contributor.authorda Silva, Benedito Borges
dc.date.accessioned2019-01-21T10:29:59Z
dc.date.available2019-01-21T10:29:59Z
dc.date.issued2016
dc.identifierhttp://dx.doi.org/10.6061/clinics/2016(02)07
dc.identifier.citationClinics. Sao paulo, v. 71, n. 2, p. 90-93, 2016.
dc.identifier.issn1807-5932
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/49516
dc.description.abstractOBJECTIVES: Vaginal atrophy and breast cancer are common conditions in postmenopausal women and tamoxifen is the standard endocrine treatment for hormone-sensitive tumors. The present study aimed to assess the effect of tamoxifen on Ki-67 protein expression in the vaginal epithelium of castrated rats. MATERIAL AND METHODS: Forty Wistar-Hannover adult, virgin, castrated rats were randomly divided into two groups, group I (control, n= 20) and group II (tamoxifen, n= 20), receiving 0.5 ml of propylene glycol and 250 mu g of tamoxifen diluted in 0.5 ml of propylene glycol, respectively, daily by gavage for 30 days. On the 31st day, the rats were euthanized and their vaginas were removed and fixed in 10% buffered formalin for the immunohistochemical study of Ki-67 protein expression. Data were analyzed by the Levene and Student's t tests (p<0.05). RESULTS: The mean index of Ki-67 expression in the rat vagina of groups I and II was 4.04 +/- 0.96 and 26.86 +/- 2.19, respectively (p<0.001). CONCLUSIONS: According to the results of the present study, tamoxifen, at the dose and treatment length used, induced a significant increase in the cell proliferation of the vaginal mucosa in castrated rats, as evaluated by Ki-67 protein expression.en
dc.format.extent90-93
dc.language.isoeng
dc.publisherHospital clinicas, univ sao paulo
dc.relation.ispartofClinics
dc.rightsAcesso aberto
dc.subjectTamoxifenen
dc.subjectRaten
dc.subjectVaginaen
dc.subjectProliferationen
dc.subjectKi-67Breast-Canceren
dc.subjectEndometriumen
dc.subjectPreventionen
dc.subjectRaloxifeneen
dc.subjectExpressionen
dc.subjectWomenen
dc.titleAnalysis of the ki-67 index in the vaginal epithelium of castrated rats treated with tamoxifenen
dc.typeArtigo
dc.description.affiliationUniversidade Federal do Piauí, Departamento de Ginecologia
dc.description.affiliationMorphology, Teresina/, PI, Brazil
dc.description.affiliationUniversidade de São Paulo, Departamento de Estatísticas, São Paulo/, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Departamento de Mastologia, São Paulo/, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Departamento de Mastologia, São Paulo/, SP, Brazil
dc.identifier.fileS1807-59322016000200090.pdf
dc.identifier.scieloS1807-59322016000200090
dc.identifier.doi10.6061/clinics/2016(02)07
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000374485200007


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