A prospective study showing an excellent response of patients with low-risk differentiated thyroid cancer who did not undergo radioiodine remnant ablation after total thyroidectomy

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dc.contributor.author Janovsky, Carolina Castro Porto Silva [UNIFESP]
dc.contributor.author Maciel, Rui M. B. [UNIFESP]
dc.contributor.author Camacho, Cleber P. [UNIFESP]
dc.contributor.author Padovani, Rosalia P. [UNIFESP]
dc.contributor.author Nakabashi, Claudia C. [UNIFESP]
dc.contributor.author Yang, Ji H. [UNIFESP]
dc.contributor.author Malouf, Eduardo Z. [UNIFESP]
dc.contributor.author Ikejiri, Elza S. [UNIFESP]
dc.contributor.author Mamone, M. Conceicao O. C. [UNIFESP]
dc.contributor.author Wagner, Jairo
dc.contributor.author Andreoni, Danielle M. [UNIFESP]
dc.contributor.author Biscolla, Rosa Paula M. [UNIFESP]
dc.date.accessioned 2019-01-21T10:29:52Z
dc.date.available 2019-01-21T10:29:52Z
dc.date.issued 2016
dc.identifier https://doi.org/10.1159/000442048
dc.identifier.citation European Thyroid Journal. Basel, v. 5, n. 1, p. 44-49, 2016.
dc.identifier.issn 2235-0640
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/49445
dc.description.abstract Objectives: To prospectively evaluate the outcome of patients with low-risk papillary thyroid carcinoma treated with total thyroidectomy (TT) who did not undergo radioiodine remnant ablation (RRA). Study Design: We prospectively followed up 57 patients en
dc.description.abstract 3 months after TT, thyroglobulin (Tg) assessment and neck ultrasonography (US) were performed while patients were taking L-T-4, presenting suppressed TSH. Six months after TT, patients underwent stimulated Tg testing and whole-body scan (WBS) after recombinant TSH (rhTSH). Then, 18 months after TT, the patients were evaluated by neck US and Tg under TSH between 0.5 and 2.0 mIU/ml. Two years after TT, we performed another rhTSH assessment, measuring Tg and making a WBS. The patients were then annually monitored with neck US and Tg measurement under TSH between 0.5 and 2.0 mIU/l for 36-84 months. Results: Neck US of all patients, 3 months after TT, presented no evidence of abnormal residual tissues or metastatic lymph nodes (negative neck US) en
dc.description.abstract at this time, the mean Tg level was 0.42 ng/ml. Six months after surgery, after rhTSH, the mean thyroid bed uptake was 1.82%, and Tg levels ranged from 0.10 to 22.30 ng/ml (mean, 2.89 ng/ml). The patients were followed up without any sign of recurrence (negative neck US and stable or decreasing Tg levels). During the ongoing follow-up, the Tg trend was stable or decreasing, independently of the initial suppressed or stimulated Tg level, or WBS uptake. Conclusions: In patients with low-risk differentiated thyroid cancer, who were operated by TT and who did not undergo RRA, an excellent response to treatment may be confirmed by annual neck US and Tg trend. (C) 2015 European Thyroid Association Published by S. Karger AG, Basel en
dc.description.sponsorship Brazilian Ministry of Health [25000.168513/2008-11]
dc.format.extent 44-49
dc.language.iso eng
dc.publisher Future Sci Ltd
dc.relation.ispartof European Thyroid Journal
dc.rights Acesso aberto
dc.subject Low-Risk Thyroid Carcinoma en
dc.subject Thyroglobulin en
dc.subject Thyroglobulin Temporal Trend en
dc.subject Radioiodine Remnant Ablation en
dc.subject Neck UltrasoundLong-Term Impact en
dc.subject Radioactive Iodine en
dc.subject Increasing Incidence en
dc.subject Therapy en
dc.subject Papillary en
dc.subject Association en
dc.subject Surveillance en
dc.subject Recurrence en
dc.subject Adjuvant en
dc.subject Update en
dc.title A prospective study showing an excellent response of patients with low-risk differentiated thyroid cancer who did not undergo radioiodine remnant ablation after total thyroidectomy en
dc.type Artigo
dc.description.affiliation Thyroid Diseases Center and Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo
dc.description.affiliation Thyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil
dc.description.affiliationUnifesp Thyroid Diseases Center and Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Pedro de Toledo 669,11th Floor, BR-04039032 Sao Paulo, SP, Brazil.
dc.description.sponsorshipID Brazilian Ministry of Health: 25000.168513/2008-11
dc.identifier.doi 10.1159/000442048
dc.description.source Web of Science
dc.identifier.wos WOS:000381685300007



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