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Phytochemical analysis of hydroethanolic extract of turnera diffusa willd and evaluation of its effects on astrocyte cell death

Análise fitoquímica do extrato hidroetanólico de Turnera diffusa Willd e avaliação de seus efeitos na morte de astrócitos

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Date
2016
Author
Bezerra, Andreia Gomes [UNIFESP]
Negri, Giuseppina [UNIFESP]
Duarte-Almeida, Joaquim Mauricio
Smaili, Soraya Soubhi [UNIFESP]
Carlini, Elisaldo Araujo [UNIFESP]
Type
Artigo
ISSN
1679-4508
Is part of
Einstein-Sao Paulo
DOI
10.1590/S1679-45082016AO3386
Metadata
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Abstract
Objective: To evaluate the phytochemical composition of hydroethanolic extracts from powdered aerial parts of Turnera diffusa Willd (Turneraceae
 
T. diffusa), as well as its toxicity in astrocytes. Methods: Chemical analyses of hydroethanolic extract from powdered aerial parts of T. diffusa were carried out using HPLC-DAD-ESI-MS/MS. In vitro assays using astrocytes culture were performed to evaluate cell death. Results: Flavone-C, O-diglycosides, such as, luteolin-8-C-[6-deoxy-2-O-rhamnosyl]-xylo-hexos-3-uloside, apigenin-8-C-[ 6-deoxy-2-O-rhamnosyl]-xylo-hexos-3-uloside and apigenin-7-O-6"-p-coumaroylglucoside were the main compounds found in this hydroethanolic extract. Concentration time-effect demonstrated the toxicity of this extract at a concentration of 1,000 mu g/mL in astrocyte culture, after 6 and 24 hours of incubation. Conclusion: In phytochemical analyses, important antioxidants (mainly flavonoids) were observed. T. diffusa extracts presented cytotoxic effect in high concentrations, leading to increased cell death in astrocyte culture.
 
Citation
Einstein-Sao Paulo. Sao paulo sp, v. 14, n. 1, p. 56-63, 2016.
Keywords
Cognition/Drug Effects
Plant Extracts/Toxicity
Protective Agents/Toxicity
Antioxidants
Cell Death/Drug EffectsPerformance Liquid-Chromatography
Quadrupole Mass-Spectrometry
Ultraviolet Uv Radiation
In-Vitro Model
Phenolic-Compounds
Electrospray-Ionization
Antioxidant Properties
Acid-Derivatives
Oxidative Stress
Quality-Control
Sponsorship
Associacao Fundo de Incentivo a Psicofarmacologia (AFIP)
Centro Brasileiro de Informacoes sobre Drogas Psicotropicas (CEBRID)
Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
URI
http://repositorio.unifesp.br/handle/11600/49379
Collections
  • EPM - Artigos [17701]

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