Acarbose promotes remission of both early and late dumping syndromes in post-bariatric patients

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dc.contributor.author Cadegiani, Flavio A. [UNIFESP]
dc.contributor.author Silva, Osvalmir Sa
dc.date.accessioned 2019-01-21T10:29:41Z
dc.date.available 2019-01-21T10:29:41Z
dc.date.issued 2016
dc.identifier https://doi.org/10.2147/DMSO.S123244
dc.identifier.citation Diabetes Metabolic Syndrome And Obesity-Targets And Therapy. Albany, v. 9, p. 443-446, 2016.
dc.identifier.issn 1178-7007
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/49329
dc.description.abstract Objective: Acarbose is a glucosidase inhibitor that slows carbohydrate digestion. It could thus be effective to promote remission of dumping syndrome (DS). Previous studies associating acarbose and late dumping, although not early dumping, have been reported. Herein, we aimed to evaluate the role of acarbose in dumping syndrome prevention and treatment and in resistive exercises resistance in bariatric subjects. Methods: Bariatric patients with DS and complete adherence to diet plan and resistive exercises were included (n=25). Number of early and late episodes, self-referred intensity of each episode, and ability to increase intensity of resistive exercise were evaluated, on a 0-10 scale. Acarbose was administered orally (50 mg) for 6 months, 4-5 times a day before meals. Results: Acarbose administration was associated with a decrease in the number of early (2.18-0.31) and late (2.79-0.12) episodes per week and intensity of each episode (6.10-1.65) and an increase in the ability to perform resistive exercises (3.03-7.12). Complete remission of DS was seen in 21 patients (84%), which persisted for 6 months with the use of acarbose. Conclusion: Acarbose prevented dumping in almost all studied subjects and helped improve exercise capacity. en
dc.format.extent 443-446
dc.language.iso eng
dc.publisher Czech Acad Sci, Inst Entomology
dc.relation.ispartof Diabetes Metabolic Syndrome And Obesity-Targets And Therapy
dc.rights Acesso aberto
dc.subject Dumping Syndrome en
dc.subject Bariatric Surgery en
dc.subject Post-Bariatric en
dc.subject ObesityGastric Bypass en
dc.subject Hypoglycemia en
dc.subject Diagnosis en
dc.subject Pathophysiology en
dc.subject Octreotide en
dc.subject Surgery en
dc.subject Therapy en
dc.title Acarbose promotes remission of both early and late dumping syndromes in post-bariatric patients en
dc.type Artigo
dc.description.affiliation Division of Endocrinology and Metabolism, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP
dc.description.affiliation Corpometria Institute, an Obesity and Endocrinology Center, Brasilia, DF, Brazil
dc.description.affiliationUnifesp Division of Endocrinology and Metabolism, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, R Pedro de Toledo 781, BR-04039032 Sao Paulo, SP, Brazil.
dc.identifier.file WOS000389895400001.pdf
dc.identifier.doi 10.2147/DMSO.S123244
dc.description.source Web of Science
dc.identifier.wos WOS:000389895400001



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