The emerging role of mirnas and their clinical implication in biliary tract cancer

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Date
2016Author
Ferreira Martins, Nina Nayara
da Silva Oliveira, Kelly Cristina
Bona, Amanda Braga
Cardoso Smith, Marilia de Arruda [UNIFESP]
Ishak, Geraldo
Assumpcao, Paulo Pimentel
Burbano, Rommel Rodriguez
Calcagno, Danielle Queiroz
Type
RevisãoISSN
1687-6121Is part of
Gastroenterology Research And PracticeDOI
10.1155/2016/9797410Metadata
Show full item recordAbstract
Biliary tract cancers are aggressive malignancies that include gallbladder cancer and tumors of intra-and extrahepatic ducts and have a poor prognosis. Surgical resection remains themain curative therapy. Nevertheless, numerous patients experience recurrence even after radical surgery. This scenario drives the research to identify biliary tract cancer biomarkers despite the limited progress that has been made. Recently, a large number of studies have demonstrated that deregulated expression of microRNAs is closely associated with cancer development and progression. In this review, we highlight the role and importance of microRNAs in biliary tract cancers with an emphasis on utilizing circulating microRNAs as potential biomarkers. Additionally, we report several singlenucleotide polymorphisms in microRNA genes that are associated with the susceptibility of biliary tract tumors.
Citation
Gastroenterology Research And Practice. New york, 2016.Keywords
Intrahepatic Cholangiocarcinoma CellsNorth Indian Population
Gallbladder Cancer
Tumor-Suppressor
Gastric-Cancer
Genetic-Variants
Mesenchymal Transition
Epigenetic Regulation
Down-Regulation
C-Myc
Sponsorship
Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
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- EPM - Artigos [17709]