Cryopreserved adipose tissue-derived stromal/stem cells: potential for applications in clinic and therapy

Date
2016Author
Zanata, Fabiana [UNIFESP]
Shaik, Shahensha
Devireddy, Ram V.
Wu, Xiying
Ferreira, Lydia Masako [UNIFESP]
Gimble, Jeffrey M.
Type
ArtigoCapítulo de livro
ISSN
0065-2598Is part of
Biobanking And Cryopreservation Of Stem CellsDOI
10.1007/978-3-319-45457-3_11Metadata
Show full item recordAbstract
Adipose-Derived Stromal/Stem Cells (ASC) have considerable potential for regenerative medicine due to their abilities to proliferate, differentiate into multiple cell lineages, high cell yield, relative ease of acquisition, and almost no ethical concerns since they are derived from adult tissue. Storage of ASC by cryopreservation has been well described that maintains high cell yield and viability, stable immunophenotype, and robust differentiation potential post-thaw. This ability is crucial for banking research and for clinical therapeutic purposes that avoid the morbidity related to repetitive liposuction tissue harvests. ASC secrete various biomolecules such as cytokines which are reported to have immunomodulatory properties and therapeutic potential to reverse symptoms of multiple degenerative diseases/disorders. Nevertheless, safety regarding the use of these cells clinically is still under investigation. This chapter focuses on the different aspects of cryopreserved ASC and the methods to evaluate their functionality for future clinical use.
Citation
Biobanking And Cryopreservation Of Stem Cells. Cham, v. 951, p. 137-146, 2016.Keywords
Adipose-Derived Stromal/Stem CellsRegenerative Medicine
Adipose Tissue
Human Cells
Cell Differentiation
Immunophenotype
Cryopreservation
Clinical TrialsAdult Stem-Cells
Experimental Autoimmune Encephalomyelitis
International-Society
Crohns Fistula
Autologous Transplantation
Assisted Lipotransfer
Stem/Stromal Cells
Position Statement
Calvarial Defects
Vascular Fraction
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