Marcadores de angiogênese e dopplervelocimetria útero placentária em pacientes com restrição do crescimento fetal

Abstract

Objective: Assessing the levels of sFlt-1, sEng, adiponectin, ADAM-12, PAPP-A, ANGI-2, VEGF, TGF-? and PP13 in pregnant women with fetal growth restriction (FGR) and controls. Methods: This case?control study included 66 patients with FGR and 64 healthy controls at 24-41 weeks´ gestation. Maternal serum levels of sFlt-1, sEng, adiponectin, ADAM-12, PAPP-A, ANGI-2, VEGF, PP13 and TGF-? were determined by ELISA method and uterine artery Doppler studies were performed. Results: Concentrations of sFlt-1, sEng, PAPP-A were significantly higher in FGR patients than controls (p<0.0001, p=0.02 and p=0.03, respectively). Concentration of ADAM-12, ANGI-2 (p=0.05 and p<0.0001) were significantly lower in FGR than controls. Increased sEng concentrations were correlated with abnormal uterine Doppler in FGR. Adiponectin and TGF-? were not associated with any analyzed parameters. Conclusion: Patients with FGR showed increased serum levels of sFlt-1, sEng and PAPP-A and decreased levels of ADAM-12 and ANGI-2. Moreover, we observed a positive association between elevated concentrations of sEng and changing impedance uterine artery Dopplervelocimetry.