Purple carrot extract protects against cadmium intoxication in multiple organs of rats: Genotoxicity, oxidative stress and tissue morphology analyses
Nenhuma Miniatura disponível
Data
2016
Autores
Claudio, Samuel Range| [UNIFESP]
Yamamura, Hirochi [UNIFESP]
Morais, Damila Rodrigues
Bataglion, Giovana Anceski
Eberlin, Marcos Nogueira
Peres, Rogerio Correa [UNIFESP]
Oshima, Celina Tizuko Fujiyama [UNIFESP]
Ribeiro, Daniel Araki [UNIFESP]
Gollucke, Andrea Pittelli Boiago [UNIFESP]
Orientadores
Tipo
Artigo
Título da Revista
ISSN da Revista
Título de Volume
Resumo
The aim of this study was to investigate if purple carrot extract is able to protect against the noxious activities induced by cadmium exposure in multiple organs of rats. For this purpose, histopathological analysis, genotoxicity and oxidative status were investigated in this setting. A total of twenty Wistar rats weighing 250 g on the average, and 8 weeks age were distributed into four groups (n=5), as follows: Control group (non-treated group, CTRL) Cadmium group (Cd) and Purple carrot extract groups at 400 mg/L or 800 mg/L. Histopathological analysis revealed that liver from animals treated with purple carrot extract improved tissue degeneration induced by cadmium intoxication. Genetic damage was reduced in blood and hepatocytes as depicted by comet and micronucleus assays in animals treated with purple carrot extract. SOD-CuZn and cytocrome C gene expression increased in groups treated with purple carrot extract. Purple carrot extract also reduced the 80HdG levels in liver cells when compared to cadmium group. Taken together, our results demonstrate that purple carrot extract is able to protect against cadmium intoxication by means of reducing tissue regeneration, genotoxicity and oxidative stress in multiple organs of Wistar rats.
Descrição
Citação
Journal Of Trace Elements In Medicine And Biology. Jena, v. 33, p. 37-47, 2016.