Effects of moderate exercise on biochemical, morphological, and physiological parameters of the pancreas of female mice with estrogen deprivation and dyslipidemia
Veloso, Aparecida Gabriela Bexiga
Lima, Nathalia Edviges Alves
Ornelas, Elisabete de Marco
Cardoso, Clever Gomes
Marques, Mara Rubia
Reis, Beatriz da Costa Aguiar Alves
Fonseca, Fernando Luiz Affonso [UNIFESP]
Maifrino, Laura Beatriz Mesiano
MetadataShow full item record
Menopausal women are at high risk of developing heart disease. However, physical exercise practice can reverse this scenario. We evaluated the biochemical, morphological, and physiological effects of moderate aerobic physical exercise on the pancreas of knockout mice for LDL receptor with estrogen deprivation by ovariectomy. Animals were divided into six groups (n = 5): sedentary non-ovariectomized controlsedentary ovariectomized controltrained ovariectomized controlsedentary non-ovariectomized LDL-R knockoutsedentary ovariectomized LDL-R knockoutand trained ovariectomized LDL-R knockout. Physical exercise practice promoted improvement in biometric and biochemical parameters analyzed, with reduction of visceral adipose tissue and VLDL, triglycerides, total cholesterol, and blood glucose levels. In addition, physical exercise practice altered the morphology of pancreatic islets and improved their response to the effects of menopause. Thus, physical exercise practice was fundamental to minimize the effects of dyslipidemia associated with ovariectomy in the pancreatic tissue of LDL-R knockout animals, contributing to reduce the risk of developing cardiac diseases in the menopause period.
CitationMedical Molecular Morphology. Tokyo, v. 51, n. 2, p. 118-127, 2018.
- ICAQF - Artigos