Chemiexcitation and Its Implications for Disease
Brash, Douglas E.
Goncalves, Leticia C. P.
Bechara, Etelvino José Henriques [UNIFESP]
MetadataShow full item record
Quantum mechanics rarely extends to molecular medicine. Recently, the pigment melanin was found to be susceptible to chemiexcitation, in which an electron is chemically excited to a high-energy molecular orbital. In invertebrates, chemiexcitation causes bioluminescencein mammals, a higher-energy process involving melanin transfers energy to DNA without photons, creating the lethal and mutagenic cyclobutane pyrimidine dimer that can cause melanoma. This process is initiated by NO center dot and O-2(center dot-) radicals, the formation of which can be triggered by ultraviolet light or inflammation. Several chronic diseases share two properties: inflammation generates these radicals across the tissue, and the diseased cells lie near melanin. We propose that chemiexcitation may be an upstream event in numerous human diseases.
CitationTrends In Molecular Medicine. Oxford, v. 24, n. 6, p. 527-541, 2018.
SponsorshipLEO Foundation, Ballerup, Denmark
Sao Paulo Research Foundation (FAPESP)
Cold Spring Harbor Laboratory
National Institute of Arthritis and Musculoskeletal and Skin Diseases
- ICAQF - Artigos