Show simple item record

dc.contributor.authorChiba, Akemi Kuroda [UNIFESP]
dc.contributor.authorBordin, J. O.
dc.contributor.authorKuwano, S. T.
dc.contributor.authorFigueiredo, M. S.
dc.contributor.authorCarvalho, K. I.
dc.contributor.authorVieira, JPB
dc.contributor.authorKerbauy, J.
dc.date.accessioned2018-06-18T12:15:03Z
dc.date.available2018-06-18T12:15:03Z
dc.date.issued2000-09-01
dc.identifierhttp://dx.doi.org/10.1046/j.1365-3148.2000.00254.x
dc.identifier.citationTransfusion Medicine. Oxford: Blackwell Science Ltd, v. 10, n. 3, p. 207-212, 2000.
dc.identifier.issn0958-7578
dc.identifier.urihttp://repositorio.unifesp.br/11600/45671
dc.description.abstractThe frequencies of human platelet-specific alloantigens (HPAs) vary between different ethnic groups, and genotyping using DNA techniques has been preferred over immunophenotyping methods for population studies. Using a polymerase chain reaction with allele-specific primers (PCR-ASP) method, we determined the allelic polymorphisms of five HPA systems among 174 unrelated individuals of two different Brazilian ethnic groups including Amazon Indians (n = 95) and blood donors (n = 79). Comparison of the calculated gene frequencies of the two alleles of HPA-1, -2, -3, -4 and -5 systems for Amazon Indians and Brazilian blood donors showed that gene frequencies obtained for the two alleles of HPA-1 (P < 0.001), HPA-2 (P = 0.001) and HPA-5 (P < 0.001) were significantly different between the two groups of individuals. All natives tested carried the HPA-2a and the HPA-5a alleles, but the HPA-1b and HPA-4b alleles are absent from the Indian population. It was also observed that all blood donors carried the HPA-1a, HPA-4a and HPA-5a alleles. In conclusion, the present data indicate differences in the frequency of the HPA systems between Amazon Indians and Brazilian subjects who present a high rate of racial admixture. While the frequencies of the HPA-1 and HPA-5 genes seen in Amazon Indians are similar to those reported for Oriental populations, the frequencies of the HPAs alleles in Brazilian blood donors are comparable to those reported for populations in North America and Europe.en
dc.format.extent207-212
dc.language.isoeng
dc.publisherBlackwell Science Ltd
dc.relation.ispartofTransfusion Medicine
dc.rightsAcesso restrito
dc.subjectallelic polymorphismsen
dc.subjectAmazon Indiansen
dc.subjectblood donorsen
dc.subjecthuman platelet antigensen
dc.subjectPCR-ASPen
dc.titlePlatelet alloantigen frequencies in Amazon Indians and Brazilian blood donorsen
dc.typeArtigo
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUniv Fed Sao Paulo, Hematol & Transfus Med Serv, Escola Paulista Med, BR-04023902 Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Serv Endocrinol, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Hematol & Transfus Med Serv, Escola Paulista Med, BR-04023902 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Serv Endocrinol, Sao Paulo, Brazil
dc.identifier.doi10.1046/j.1365-3148.2000.00254.x
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000089100700006


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record