Platelet alloantigen frequencies in Amazon Indians and Brazilian blood donors

Platelet alloantigen frequencies in Amazon Indians and Brazilian blood donors

Author Chiba, Akemi Kuroda Autor UNIFESP Google Scholar
Bordin, J. O. Google Scholar
Kuwano, S. T. Google Scholar
Figueiredo, M. S. Google Scholar
Carvalho, K. I. Google Scholar
Vieira, JPB Google Scholar
Kerbauy, J. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract The frequencies of human platelet-specific alloantigens (HPAs) vary between different ethnic groups, and genotyping using DNA techniques has been preferred over immunophenotyping methods for population studies. Using a polymerase chain reaction with allele-specific primers (PCR-ASP) method, we determined the allelic polymorphisms of five HPA systems among 174 unrelated individuals of two different Brazilian ethnic groups including Amazon Indians (n = 95) and blood donors (n = 79). Comparison of the calculated gene frequencies of the two alleles of HPA-1, -2, -3, -4 and -5 systems for Amazon Indians and Brazilian blood donors showed that gene frequencies obtained for the two alleles of HPA-1 (P < 0.001), HPA-2 (P = 0.001) and HPA-5 (P < 0.001) were significantly different between the two groups of individuals. All natives tested carried the HPA-2a and the HPA-5a alleles, but the HPA-1b and HPA-4b alleles are absent from the Indian population. It was also observed that all blood donors carried the HPA-1a, HPA-4a and HPA-5a alleles. In conclusion, the present data indicate differences in the frequency of the HPA systems between Amazon Indians and Brazilian subjects who present a high rate of racial admixture. While the frequencies of the HPA-1 and HPA-5 genes seen in Amazon Indians are similar to those reported for Oriental populations, the frequencies of the HPAs alleles in Brazilian blood donors are comparable to those reported for populations in North America and Europe.
Keywords allelic polymorphisms
Amazon Indians
blood donors
human platelet antigens
Language English
Date 2000-09-01
Published in Transfusion Medicine. Oxford: Blackwell Science Ltd, v. 10, n. 3, p. 207-212, 2000.
ISSN 0958-7578 (Sherpa/Romeo, impact factor)
Publisher Blackwell Science Ltd
Extent 207-212
Access rights Closed access
Type Article
Web of Science ID WOS:000089100700006

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