Effects of the Adenosine Deaminase Polymorphism and Caffeine Intake on Sleep Parameters in a Large Population Sample
Nenhuma Miniatura disponível
Data
2011-03-01
Autores
Mazzotti, Diego Robles [UNIFESP]
Guindalini, Camila [UNIFESP]
Pellegrino, Renata [UNIFESP]
Barrueco, Karina Fonseca [UNIFESP]
Santos-Silva, Rogerio [UNIFESP]
Bittencourt, Lia Rita Azeredo [UNIFESP]
Tufik, Sergio [UNIFESP]
Orientadores
Tipo
Artigo
Título da Revista
ISSN da Revista
Título de Volume
Resumo
Study Objectives: To evaluate the association between the adenosine deaminase polymorphism, sleep architecture, and caffeine consumption.Design: Genetic association study.Setting: NAPatients or Participants: 958 participants who underwent polysomnography and genotyping.Interventions: NAMeasurements and Results: Individuals carrying the A allele who consumed caffeine in the day prior to polysomnography demonstrated higher sleep efficiency and REM sleep percentage, after adjustment for potential confounders. No effect was observed in the absence of caffeine.Conclusions: Our data support the role of the ADA G22A polymorphism in sleep, and demonstrate for the first time that caffeine may act as a modulator of its functional effects.
Descrição
Citação
Sleep. Westchester: Amer Acad Sleep Medicine, v. 34, n. 3, p. 399-402, 2011.