Modafinil Prevents Inhibitory Avoidance Memory Deficit Induced by Sleep Deprivation in Rats
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Data
2010-07-01
Autores
Moreira, Karin Monteiro [UNIFESP]
Ferreira, Tatiana Lima [UNIFESP]
Hipólide, Débora Cristina [UNIFESP]
Fomari, Raquel Vecchio [UNIFESP]
Tufik, Sergio [UNIFESP]
Menezes Oliveira, Maria Gabriela [UNIFESP]
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Study Objectives: Evaluation of modafinil effects on the inhibitory avoidance task (IA).Design: Rats were trained on a multiple trial IA task after receiving modafinil or vehicle injections. In experiment 1 they were trained with a weak protocol under baseline condition and in experiment 2, with a stronger protocol under sleep-deprivation condition.Results: In experiment 1 modafinil improved rats' acquisition whereas the retention test remained unaffected. In Experiment 2 modafinil did not interfere with training performance, but the lower dose prevented the retention impairment in sleep-deprived animals.Conclusions: Modafinil is able to improve acquisition in normal rats and reverse the long-term memory impairment induced by sleep-deprivation.
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Sleep. Westchester: Amer Acad Sleep Medicine, v. 33, n. 7, p. 990-993, 2010.