Modafinil Prevents Inhibitory Avoidance Memory Deficit Induced by Sleep Deprivation in Rats

Modafinil Prevents Inhibitory Avoidance Memory Deficit Induced by Sleep Deprivation in Rats

Author Moreira, Karin Monteiro Autor UNIFESP Google Scholar
Ferreira, Tatiana Lima Autor UNIFESP Google Scholar
Hipólide, Débora Cristina Autor UNIFESP Google Scholar
Fomari, Raquel Vecchio Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Menezes Oliveira, Maria Gabriela Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do ABC (UFABC)
Univ Groningen, Univ Med Ctr Groningen
Abstract Study Objectives: Evaluation of modafinil effects on the inhibitory avoidance task (IA).Design: Rats were trained on a multiple trial IA task after receiving modafinil or vehicle injections. In experiment 1 they were trained with a weak protocol under baseline condition and in experiment 2, with a stronger protocol under sleep-deprivation condition.Results: In experiment 1 modafinil improved rats' acquisition whereas the retention test remained unaffected. In Experiment 2 modafinil did not interfere with training performance, but the lower dose prevented the retention impairment in sleep-deprived animals.Conclusions: Modafinil is able to improve acquisition in normal rats and reverse the long-term memory impairment induced by sleep-deprivation.
Keywords Cognitive enhancer
emotional memory
Language English
Date 2010-07-01
Published in Sleep. Westchester: Amer Acad Sleep Medicine, v. 33, n. 7, p. 990-993, 2010.
ISSN 0161-8105 (Sherpa/Romeo, impact factor)
Publisher Amer Acad Sleep Medicine
Extent 990-993
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000279365600020

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