Genetic diversity of HIV

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Data
1997-04-01
Autores
Diaz, Ricardo Sobhie [UNIFESP]
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The human immunodeficiency virus (HIV) is a retrovirus (Fam: Retroviridae), which is the causative agent of the devastating AIDS pandemics currently affecting millions of human beings. HIV rapidly evolves by several molecular mechanisms, such as mutation, hypermutation, insertions and deletions and recombination; all process actively contributing to its genetic diversity. This rapid evolutionary process, assisted by the rapid transmission through human populations, poses a significant challenge to the effective monitoring of HIV variation and AIDS control. Herein, the implications of genetic diversity related to the pathogenesis of HIV infection are addressed. The potential problems in its reliable detection by the antibody screening tests in current use, the role of a global genotyping surveillance, efforts to trace the progress of the worldwide epidemic and the rationale for future vaccines and drug trials will be discussed.
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Revista De Microbiologia. Sao Paulo: Soc Brasileira Microbiologia, v. 28, n. 2, p. 69-75, 1997.
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