Estimated prevalence of childhood end-stage renal disease in the state of Sao Paulo

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Nogueira, Paulo Cesar Koch [UNIFESP]
Feltran, Luciana de Santis
Camargo, Maria Fernanda
Leão, Eliseth Ribeiro
Benninghoven, Jennifer Regina Corrêa da Silva
Gonçalves, Natália Zuanetti
Pereira, Luiz A.
Sesso, Ricardo de Castro Cintra [UNIFESP]
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Estimated prevalence of childhood end-stage renal disease in the state of Sao PauloObjective: To estimate the prevalence of pediatric end-stage renal disease and evaluate demographics and renal disease characteristics in state of Sao Paulo over the year 2008. Methods: Observational, descriptive, and cross-sectional study based on a population sample with subjects < 18 years. The data collecting assumed three forms: 1. A questionnaire for dialysis units; 2. Search in the Transplant Center to determine the number and characteristics of patients who had been in a transplant waiting list over the study period; 3. Search in the database of patients registered at the Latin American Collaborative Registry of Pediatric Kidney Transplantation. Results: Data from 301 patients aged 9.0 +/- 5.8, including 140 girls (46.5%), resulting in an estimate prevalence of 23.4 cases per million age-related population (pmarp). The age group most frequently found was 10 to 15 years (32.2%), and urinary tract malformation was the most usual known etiology (24.9%). Most children underwent kidney transplantation (62.1%) and among subjects on dialysis, hemodialysis was predominant (71.2%). The Sistema Unico de Saude - Unified National Health System - (SUS) provided the financial support for treatments. Conclusion: The prevalence of 23.4 cases pmarp found by the authors is lower than that reported in Western world. We believe data were underestimated in the present study, as few dialysis units returned the completed questionnaire. This potential bias does not invalidate the exploratory character of results. Further mechanisms for retrospective and earlier data collecting on pediatric chronic renal disease (CRD) are needed so that the burden of this serious health condition can be appropriately sized up.
Revista Da Associacao Medica Brasileira. Sao Paulo: Assoc Medica Brasileira, v. 57, n. 4, p. 443-449, 2011.