Outlining new frontiers for the comprehension of obsessive-compulsive disorder: a review of its relationship with fear and anxiety

Outlining new frontiers for the comprehension of obsessive-compulsive disorder: a review of its relationship with fear and anxiety

Title: Outlining new frontiers for the comprehension of obsessive-compulsive disorder: a review of its relationship with fear and anxiety;
Desenhando as novas fronteiras para a compreensão do transtorno obsessivo-compulsivo: uma revisão de sua relação com o medo e a ansiedade
Author Diniz, Juliana Belo Google Scholar
Miguel, Euripedes Constantino Google Scholar
Oliveira, Amanda Ribeiro de Google Scholar
Reimer, Adriano Edgar Google Scholar
Brandao, Marcus Lira Google Scholar
Mathis, Maria Alice de Google Scholar
Batistuzzo, Marcelo Camargo Google Scholar
Costa, Daniel Lucas Conceicao Google Scholar
Hoexter, Marcelo Queiroz Autor UNIFESP Google Scholar
Institution Universidade de São Paulo (USP)
Inst Neurosci & Behav
Universidade Federal de São Paulo (UNIFESP)
Abstract Anxiety is an important component of the psychopathology of the obsessive-compulsive disorder (OCD). So far, most interventions that have proven to be effective for treating OCD are similar to those developed for other anxiety disorders. However, neurobiological studies of OCD came to conclusions that are not always compatible with those previously associated with other anxiety disorders. Objectives: The aim of this study is to review the degree of overlap between OCD and other anxiety disorders phenomenology and pathophysiology to support the rationale that guides research in this field. Results: Clues about the neurocircuits involved in the manifestation of anxiety disorders have been obtained through the study of animal anxiety models, and structural and functional neuroimaging in humans. These investigations suggest that in OCD, in addition to dysfunction in cortico-striatal pathways, the functioning of an alternative neurocircuitry, which involves amygdalo-cortical interactions and participates in fear conditioning and extinction processes, may be impaired. Conclusion: It is likely that anxiety is a relevant dimension of OCD that impacts on other features of this disorder. Therefore, future studies may benefit from the investigation of the expression of fear and anxiety by OCD patients according to their type of obsessions and compulsions, age of OCD onset, comorbidities, and patterns of treatment response.
Keywords Obsessive-Compulsive Disorder
Anxiety Disorders
Fear
Stress Disorders
Post-Traumatic
Neuroimaging
Epidemiology
Treatment
Language English
Sponsor Global Research Awards for Nicotine Dependence (GRAND) from Pfizer U.S.
Date 2012-06-01
Published in Revista Brasileira De Psiquiatria. Sao Paulo: Assoc Brasileira Psiquiatria, v. 34, p. S81-S103, 2012.
ISSN 1516-4446 (Sherpa/Romeo, impact factor)
Publisher Assoc Brasileira Psiquiatria
Extent S81-S103
Origin http://dx.doi.org/10.1590/S1516-44462012000500007
Access rights Open access Open Access
Type Review
Web of Science ID WOS:000305441200007
SciELO ID S1516-44462012000500007 (statistics in SciELO)
URI http://repositorio.unifesp.br/11600/45405

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