Does microperimetry have a prognostic value in central serous chorioretinopathy?

Does microperimetry have a prognostic value in central serous chorioretinopathy?

Author Roisman, Luiz Autor UNIFESP Google Scholar
Ribeiro, Joao C. Autor UNIFESP Google Scholar
Fechine, Francisco Vagnaldo Google Scholar
Lavinsky, Daniel Autor UNIFESP Google Scholar
Moraes, Nilva Simeren Bueno de Autor UNIFESP Google Scholar
Campos, Mauro Silveira de Queiroz Autor UNIFESP Google Scholar
Farah, Michel Eid Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Fed Ceara
Abstract Purpose: To investigate the relationship between retinal sensitivity and persistence of subretinal fluid and then to analyze microperimetry as a prognostic predictor of acute central serous chorioretinopathy.Methods: A prospective observational study. Fourteen eyes of 14 patients presenting with first episode acute central serous chorioretinopathy were enrolled and underwent ocular examination, spectral domain optical coherence tomography, and MAIA microperimetry were performed. After three months of follow-up, without any treatment, visual acuity and spectral domain optical coherence tomography macular thickness assessments and microperimetry were repeated. The main outcome was to find a relation between initial macular sensitivity and persistence of subretinal fluid. A receiver operating characteristic curve was plotted to indicate the best macular sensitivity cutoff point that would be able to predict whether a patient with acute central serous chorioretinopathy would progress to the chronic form. According to the cutoff, we calculated the sensitivity, specificity, and positive and negative predictive values for macular sensitivity as a method to predict persistence of subretinal fluid.Results: On the basis of the receiver operating characteristic curve, a cutoff of 20 dB macular sensitivity was obtained, as the best balance between sensitivity and specificity to predict chronicity. Using this cutoff, the method had a sensitivity of 71% and specificity of 100% with a positive predictive value of 100% and negative predictive value of 78%. Furthermore, it was found that eyes with acute central serous chorioretinopathy and microperimetry of less than 20 dB had a relative risk of 4.5 to develop subretinal fluid persistence.Conclusion: Microperimetry with a cutoff of 20 dB may be a useful test to predict the persistence of subretinal fluid, allowing the ophthalmologist to use treatment tools earlier, preventing extracellular damage and visual impairment.
Keywords central serous chorioretinopathy
Language English
Date 2014-04-01
Published in Retina-the Journal Of Retinal And Vitreous Diseases. Philadelphia: Lippincott Williams & Wilkins, v. 34, n. 4, p. 713-718, 2014.
ISSN 0275-004X (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 713-718
Access rights Closed access
Type Article
Web of Science ID WOS:000336960500018

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