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dc.contributor.authorTempone, André Gustavo
dc.contributor.authorSartorelli, Patricia [UNIFESP]
dc.contributor.authorTeixeira, Denise
dc.contributor.authorPrado, Frederico O
dc.contributor.authorCalixto, Ivete Arl
dc.contributor.authorLorenzi, Harri
dc.contributor.authorMelhem, Márcia Sc
dc.date.accessioned2015-06-14T13:38:41Z
dc.date.available2015-06-14T13:38:41Z
dc.date.issued2008-08-01
dc.identifierhttp://dx.doi.org/10.1590/S0074-02762008000500006
dc.identifier.citationMemórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 103, n. 5, p. 443-449, 2008.
dc.identifier.issn0074-0276
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/4516
dc.description.abstractNatural products have long been providing important drug leads for infectious diseases. Leishmaniasis is a protozoan parasitic disease found mainly in developing countries, and it has toxic therapies with few alternatives. Fungal infections have been the main cause of death in immunocompromised patients and new drugs are urgently needed. In this work, a total of 16 plant species belonging to 11 families, selected on an ethnopharmacological basis, were analyzed in vitro against Leishmania (L.) chagasi, Leishmania (L.) amazonensis, Candida krusei, and C. parapsilosis. Of these plant species, seven showed antifungal activity against C. krusei, five showed antileishmanial activity against L. chagasi and four against L. amazonensis, among them species of genus Plectranthus. Our findings confirm the traditional therapeutic use of these plants in the treatment of infectious and inflammatory disorders and also offer insights into the isolation of active and novel drug prototypes, especially those used against neglected diseases as Leishmaniasis.en
dc.format.extent443-449
dc.language.isoeng
dc.publisherInstituto Oswaldo Cruz, Ministério da Saúde
dc.relation.ispartofMemórias do Instituto Oswaldo Cruz
dc.rightsAcesso aberto
dc.subjectLeishmaniaen
dc.subjectCandidaen
dc.subjectplantsen
dc.subjectantimicrobialen
dc.subjectdrugsen
dc.subjecttherapyen
dc.titleBrazilian flora extracts as source of novel antileishmanial and antifungal compoundsen
dc.typeArtigo
dc.contributor.institutionInstituto Adolfo Lutz Serviço de Parasitologia Laboratório de Toxinologia Aplicada
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionInstituto Plantarum de Estudos da Flora
dc.description.affiliationInstituto Adolfo Lutz Serviço de Parasitologia Laboratório de Toxinologia Aplicada
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Departamento de Ciências Exatas e da Terra
dc.description.affiliationInstituto Plantarum de Estudos da Flora
dc.description.affiliationUnifespUNIFESP, Depto. de Ciências Exatas e da Terra
dc.identifier.fileS0074-02762008000500006.pdf
dc.identifier.scieloS0074-02762008000500006
dc.identifier.doi10.1590/S0074-02762008000500006
dc.description.sourceSciELO


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