The papain pocket delivery impairs the capsule fibrous healing around textured silicone implants in rats.
Moreira, Marcio [UNIFESP]
Fagundes, Djalma Jose [UNIFESP]
Long, Charles A.
Mastorakis, Nikos E.
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To study the tissue repair around the textured mammary implants under the action of papain (PA). Methods: Thirty-six Wistar rats were evaluated and randomly distributed into two groups (n = 18): papain (PA) and control (CT). Each group was equally distributed into 3 subgroups (n = 6) and observed on seventh, thirtieth-fifth and ninth pos-operative days. Each animal received a textured implant in the left dorso-axillary region (sham - SH), on were instilled 0.5 mL saline solution 0.9%, and another textured implant on the right dorso-axillary region (papain - PA), on were instilled 0.5 mL of water-soluble solution of papain. The control group (CT) received only textured implant in the left dorso-axillary region with prior instillation of 0.5 mL of saline solution 0.9%. The histological analysis of the 3 subgroups was carried out using picrosirius-red stain and an image analyzing system using the Image Pro Plus (TM) program to evaluate the thickness and maturation and deposition of collagen fibers. Immunohistochemical evaluation was performed, using micrometric reticules of Weiss (Olympus Labstore (TM)), for myofibroblasts counting only in the 90(th) day subgroup. Results: At 35(th) and 90(th) days, the papain group (PA) presented reduction on the fibrous capsule thickness around the implant, in the number of collagen fibers and myofibroblasts, comparing to the control group (CT). Conclusion: The papain drug decreased the fibrous capsule formation around the textured silicon implants in rats.
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