Decreased GH secretion and enhanced ACTH and cortisol release after ghrelin administration in Cushing's disease: comparison with GHRP-6

Decreased GH secretion and enhanced ACTH and cortisol release after ghrelin administration in Cushing's disease: comparison with GHRP-6

Author Correa-Silva, Silvia Regina Autor UNIFESP Google Scholar
Nascif, Sergio Oliva Autor UNIFESP Google Scholar
Silva, Marcos Roberto Google Scholar
Borges, Maria Helena Senger Google Scholar
Miranda, W. L. Google Scholar
Machado, A. F. Google Scholar
Lengyel, Ana Maria Judith Autor UNIFESP Google Scholar
MEDIMOND Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract GHRP-6-induced GH release is decreased in Cushing's disease (CD), and ACTH and cortisol responses are enhanced. Ghrelin stimulates GH, ACTH and cortisol release in men. We compared the GH, ACTH and cortisol responses to ghrelin and GHRP-6 in CD (n = 12) and controls (n = 9). In CD, peak GH levels (mu g/L; mean +/- SE) after ghrelin administration (7,7 +/- 2,6) were higher than those observed after GHRP-6 (2,7 +/- 1), but lower than in controls (58,4 +/- 10). Peak ACTH (pg/mL) and cortisol (mu g/dL) levels after ghrelin (187 +/- 35 +/- 4,5) were higher than in controls (93 +/- 32; 18,9 +/- 1,1), but similar to GHRP-6 (185 +/- 57; 33,3 +/- 4,7). The higher GH response to ghrelin compared to GHRP-6 in CD suggests activation of additional intracellular pathways by ghrelin. The same ACTH and cortisol releasing mechanisms are probably stimulated by both peptides.
Language English
Date 2004-01-01
Published in Proceedings Of The 12th International Congress Of Endocrinology. Bologna: Medimond Publishing Co, p. 913-917, 2004.
Publisher Medimond Publishing Co
Extent 913-917
Access rights Closed access
Type Conference paper
Web of Science ID WOS:000227355300155
URI http://repositorio.unifesp.br/11600/45126

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