• RI - Unifesp
    • Documentos
    • Tutoriais
    • Perguntas frequentes
    • Atendimento
    • Equipe
    • português (Brasil)
    • English
    • español
  • Sobre
    • RI Unifesp
    • Documentos
    • Tutoriais
    • Perguntas frequentes
    • Atendimento
    • Equipe
  • English 
    • português (Brasil)
    • English
    • español
    • português (Brasil)
    • English
    • español
  • Login
View Item 
  •   DSpace Home
  • Escola Paulista de Medicina (EPM)
  • EPM - Outras produções
  • View Item
  •   DSpace Home
  • Escola Paulista de Medicina (EPM)
  • EPM - Outras produções
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Decreased GH secretion and enhanced ACTH and cortisol release after ghrelin administration in Cushing's disease: comparison with GHRP-6

Thumbnail
Date
2004-01-01
Author
Correa-Silva, Silvia Regina [UNIFESP]
Nascif, Sergio Oliva [UNIFESP]
Silva, Marcos Roberto
Borges, Maria Helena Senger
Miranda, W. L.
Machado, A. F.
Lengyel, Ana Maria Judith [UNIFESP]
MEDIMOND
Type
Trabalho apresentado em evento
Is part of
Proceedings Of The 12th International Congress Of Endocrinology
Metadata
Show full item record
Abstract
GHRP-6-induced GH release is decreased in Cushing's disease (CD), and ACTH and cortisol responses are enhanced. Ghrelin stimulates GH, ACTH and cortisol release in men. We compared the GH, ACTH and cortisol responses to ghrelin and GHRP-6 in CD (n = 12) and controls (n = 9). In CD, peak GH levels (mu g/L; mean +/- SE) after ghrelin administration (7,7 +/- 2,6) were higher than those observed after GHRP-6 (2,7 +/- 1), but lower than in controls (58,4 +/- 10). Peak ACTH (pg/mL) and cortisol (mu g/dL) levels after ghrelin (187 +/- 35 +/- 4,5) were higher than in controls (93 +/- 32; 18,9 +/- 1,1), but similar to GHRP-6 (185 +/- 57; 33,3 +/- 4,7). The higher GH response to ghrelin compared to GHRP-6 in CD suggests activation of additional intracellular pathways by ghrelin. The same ACTH and cortisol releasing mechanisms are probably stimulated by both peptides.
Citation
Proceedings Of The 12th International Congress Of Endocrinology. Bologna: Medimond Publishing Co, p. 913-917, 2004.
URI
http://repositorio.unifesp.br/11600/45126
Collections
  • EPM - Outras produções [1892]

DSpace software copyright © 2002-2016  DuraSpace
Contact Us
Theme by 
Atmire NV
 

 

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsBy Submit DateThis CollectionBy Issue DateAuthorsTitlesSubjectsBy Submit Date

My Account

Login

Statistics

View Usage Statistics

DSpace software copyright © 2002-2016  DuraSpace
Contact Us
Theme by 
Atmire NV