Decreased GH secretion and enhanced ACTH and cortisol release after ghrelin administration in Cushing's disease: comparison with GHRP-6

Date
2004-01-01Author
Correa-Silva, Silvia Regina [UNIFESP]
Nascif, Sergio Oliva [UNIFESP]
Silva, Marcos Roberto
Borges, Maria Helena Senger
Miranda, W. L.
Machado, A. F.
Lengyel, Ana Maria Judith [UNIFESP]
MEDIMOND
Type
Trabalho apresentado em eventoIs part of
Proceedings Of The 12th International Congress Of EndocrinologyMetadata
Show full item recordAbstract
GHRP-6-induced GH release is decreased in Cushing's disease (CD), and ACTH and cortisol responses are enhanced. Ghrelin stimulates GH, ACTH and cortisol release in men. We compared the GH, ACTH and cortisol responses to ghrelin and GHRP-6 in CD (n = 12) and controls (n = 9). In CD, peak GH levels (mu g/L; mean +/- SE) after ghrelin administration (7,7 +/- 2,6) were higher than those observed after GHRP-6 (2,7 +/- 1), but lower than in controls (58,4 +/- 10). Peak ACTH (pg/mL) and cortisol (mu g/dL) levels after ghrelin (187 +/- 35 +/- 4,5) were higher than in controls (93 +/- 32; 18,9 +/- 1,1), but similar to GHRP-6 (185 +/- 57; 33,3 +/- 4,7). The higher GH response to ghrelin compared to GHRP-6 in CD suggests activation of additional intracellular pathways by ghrelin. The same ACTH and cortisol releasing mechanisms are probably stimulated by both peptides.
Citation
Proceedings Of The 12th International Congress Of Endocrinology. Bologna: Medimond Publishing Co, p. 913-917, 2004.Collections
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