The effects of ghrelin on GH, ACTH and cortisol release in thyrotoxicosis

The effects of ghrelin on GH, ACTH and cortisol release in thyrotoxicosis

Author Nascif, Sergio Oliva Autor UNIFESP Google Scholar
Correa-Silva, Silvia Regina Autor UNIFESP Google Scholar
Silva, Marcos Roberto da Google Scholar
Borges, Maria Helena Senger Google Scholar
Lengyel, Ana Maria Judith Autor UNIFESP Google Scholar
MEDIMOND Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract In thyrotoxicosis there is an impaired GH response to several stimuli. Ghrelin is a potent GH secretagogue and it also induces ACTH and cortisol release in men. We evaluated the effects of ghrelin in 6 hyperthyroid patients and in 8 controls. In thyrotoxicosis peak GH (mu g/L; mean +/- SE) levels after ghrelin administration were significantly lower than those observed in controls (20.9 +/- 3.5 vs. 62.6 +/- 10.3). The same pattern was seen with AUC (mu g/L.120min) values (871 +/- 141 vs. 3667 +/- 662). ACTH and cortisol levels after ghrelin injection were similar in thyrotoxic patients and controls. In summary, our data shows that ghrelin-induced GH release is decreased in thyrotoxicosis, while ACTH and cortisol responsiveness is maintained. This could suggest that thyroid hormone excess interferes with GH releasing pathways activated by ghrelin.
Language English
Date 2004-01-01
Published in Proceedings Of The 12th International Congress Of Endocrinology. Bologna: Medimond Publishing Co, p. 907-911, 2004.
Publisher Medimond Publishing Co
Extent 907-911
Access rights Closed access
Type Conference paper
Web of Science ID WOS:000227355300154

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