The effects of ghrelin on GH, ACTH and cortisol release in thyrotoxicosis

Date
2004-01-01Author
Nascif, Sergio Oliva [UNIFESP]
Correa-Silva, Silvia Regina [UNIFESP]
Silva, Marcos Roberto da
Borges, Maria Helena Senger
Lengyel, Ana Maria Judith [UNIFESP]
MEDIMOND
Type
Trabalho apresentado em eventoIs part of
Proceedings Of The 12th International Congress Of EndocrinologyMetadata
Show full item recordAbstract
In thyrotoxicosis there is an impaired GH response to several stimuli. Ghrelin is a potent GH secretagogue and it also induces ACTH and cortisol release in men. We evaluated the effects of ghrelin in 6 hyperthyroid patients and in 8 controls. In thyrotoxicosis peak GH (mu g/L; mean +/- SE) levels after ghrelin administration were significantly lower than those observed in controls (20.9 +/- 3.5 vs. 62.6 +/- 10.3). The same pattern was seen with AUC (mu g/L.120min) values (871 +/- 141 vs. 3667 +/- 662). ACTH and cortisol levels after ghrelin injection were similar in thyrotoxic patients and controls. In summary, our data shows that ghrelin-induced GH release is decreased in thyrotoxicosis, while ACTH and cortisol responsiveness is maintained. This could suggest that thyroid hormone excess interferes with GH releasing pathways activated by ghrelin.
Citation
Proceedings Of The 12th International Congress Of Endocrinology. Bologna: Medimond Publishing Co, p. 907-911, 2004.Collections
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