Treatment with dexamethasone alters yawning behavior induced by cholinergic but not dopaminergic agonist

Date
1999-01-15Author
Hipólide, Débora Cristina [UNIFESP]
Lobo, Leticia Leite [UNIFESP]
Medeiros, Roberta de
Neumann, Beatrice Rosaura Guaragna [UNIFESP]
Tufik, Sergio [UNIFESP]
Type
ArtigoISSN
0031-9384Is part of
Physiology & BehaviorDOI
10.1016/S0031-9384(98)00234-0Metadata
Show full item recordAbstract
Because stressful manipulations have been reported to modify drug-induced yawning, the present study investigated the effects of single and repeated treatment with a synthetic glucocorticoid, dexamethasone (DEXA) on apomorphine- and pilocarpine-induced yawning in male rats. Neither single nor repeated treatment with DEXA altered apomorphine-induced yawning. Single administration of DEXA, however, resulted in an increased number of yawns induced by pilocarpine. Conversely, repeated administration of DEXA led to a decreased number of yawns induced by pilocarpine. In conclusion, the present findings show that dopaminergic and cholinergic are distinctly altered by DEXA, in terms of yawning behavior when animals received DEXA. (C) 1999 Elsevier Science, Inc.
Citation
Physiology & Behavior. Oxford: Pergamon-elsevier Science Ltd, v. 65, n. 4-5, p. 829-832, 1999.Collections
- EPM - Artigos [17701]