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dc.contributor.authorSantos, Wilson da Costa
dc.contributor.authorGarcez-do-Carmo, Lucia [UNIFESP]
dc.contributor.authorSilva, Eliane Cristina da [UNIFESP]
dc.contributor.authorPascual, Ricardo de
dc.contributor.authorJurkiewicz, Neide Hyppolito [UNIFESP]
dc.contributor.authorJurkiewicz, Aron [UNIFESP]
dc.contributor.authorGandia, Luis
dc.identifier.citationPharmacological Reports. Krakow: Polish Acad Sciences Inst Pharmacology, v. 61, n. 2, p. 325-329, 2009.
dc.description.abstractThe inhibitory effect of agmatine on electrically induced contractions was studied in vas deferens of Adra 2a transgenic mice lacking alpha(2A)-adrenoceptors. Agmatine and clonidine caused a concentration-dependent inhibition of twitches. However, while agmatine showed a similar pIC(50) value in control and transgenic mice, the pIC(50) value for clonidine was about 30-fold lower in knockout mice. In both strains, yohimbine shifted the curve for clonidine, but not for agmatine, even when a 100-fold higher concentration of yohimbine was employed. Our results indicate that inhibition by agmatine in mouse vas deferens is not simply due to interactions with alpha(2)-adrenoceptors in our experimental conditions.en
dc.description.sponsorshipFundacion Teofilo Hernando (Spain)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.publisherPolish Acad Sciences Inst Pharmacology
dc.relation.ispartofPharmacological Reports
dc.rightsAcesso restrito
dc.subjectvas deferensen
dc.subjecttransgenic (knockout) miceen
dc.titleUse of transgenic (knockout) mice reveals a site distinct from the alpha(2A)-adrenoceptors for agmatine in the vas deferensen
dc.contributor.institutionUniversidade Federal Fluminense (UFF)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionFac Med
dc.description.affiliationUniv Fed Fluminense, Fac Farm, Dept Farm & Adm Farmaceut, BR-24241000 Niteroi, RJ, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Farmacol, BR-04021023 Sao Paulo, Brazil
dc.description.affiliationFac Med, Dept Farmacol & Terapeut, Inst Teofilo Hernando, Madrid 28029, Spain
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Farmacol, BR-04021023 Sao Paulo, Brazil
dc.description.sourceWeb of Science

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