A GSTP1 functional variant associated with cocaine dependence in a Brazilian population

A GSTP1 functional variant associated with cocaine dependence in a Brazilian population

Author Guindalini, Camila Autor UNIFESP Google Scholar
O'Gara, Colin Google Scholar
Laranjeira, Ronaldo Autor UNIFESP Google Scholar
Collier, David Google Scholar
Castelo, Adauto Autor UNIFESP Google Scholar
Vallada, Homero Autor UNIFESP Google Scholar
Breen, Gerome Google Scholar
Institution Kings Coll London
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract Cocaine dependence aetiology is complex and genetically influenced. We hypothesize that, for many users, efficient metabolism of cocaine and its toxic byproducts aids persistent cocaine use, such as that leading to dependence. The glutathione-S-transferases-in particular, GST-Pi-may be important in preventing cocaine and alcohol-induced oxidative damage. We genotyped a GST-Pi functional polymorphism (Ile105Val) in 654 male cocaine users and 572 controls from Brazil. Genotype and allele frequencies of Ile105Val differed significantly (chi(2) = 6.74; P=0.03 and chi(2)=6.54; P=0.01, respectively). Ile/Ile cocaine dependents had an OR=1.31 (95%Cl: 1.04-1.65), and Ile/Ile dependents consuming > 50 units alcohol weekly an OR of 1.44 (95% CI:106-1.96). Population stratification was assessed and did not affect the results. These data require replication but do suggest that the high activity Ile105 GST-Pi allele may influence the aetiology and development of cocaine dependence.
Keywords cocaine dependence
addiction genetics
Language English
Date 2005-12-01
Published in Pharmacogenetics And Genomics. Philadelphia: Lippincott Williams & Wilkins, v. 15, n. 12, p. 891-893, 2005.
ISSN 1744-6872 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 891-893
Origin http://dx.doi.org/10.1097/01213011-200512000-00007
Access rights Closed access
Type Article
Web of Science ID WOS:000233534800007
URI http://repositorio.unifesp.br/11600/45086

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